Table 2 Patients’ glucose-lowering therapy at the time of HOMA2 by pathophysiologic profiles (N = 147)
Variable | Total (N = 147) Median [P25; P75] or n (%) | Profile 1 (n = 16) Median [P25; P75] or n (%) | Profile 2 (n = 14) Median [P25; P75] or n (%) | Profile 3 (n = 23) Median [P25; P75] or n (%) | Profile 4 (n = 29) Median [P25; P75] or n (%) | Profile 5 (n = 28) Median [P25; P75] or n (%) | Profile 6 (n = 37) Median [P25; P75] or n (%) |
|---|---|---|---|---|---|---|---|
Number of GLT drugs* | 2.00 [1.00; 2.00] | 1.00 [1.00; 1.75] | 1.00 [0.00; 2.00] | 1.00 [0.00; 2.00] | 2.00 [1.00; 2.00] | 1.00 [1.00; 2.00] | 2.00 [2.00; 2.00] |
Lifestyle changes only | 21 (14.3) | 3 (18.8) | 4 (28.6) | 7 (30.4) | 1 (3.4) | 6 (21.4) | 0 (0.0) |
Monotherapy | 52 (35.4) | 9 (56.3) | 5 (35.7) | 8 (34.8) | 12 (41.4) | 11 (39.3) | 7 (18.9) |
Bitherapy | 61 (41.5) | 3 (18.8) | 5 (35.7) | 6 (26.1) | 13 (44.8) | 11 (39.3) | 23 (62.2) |
Tritherapy | 13 (8.8) | 1 (6.3) | 0 (0.0) | 2 (8.7) | 3 (10.3) | 0 (0.0) | 7 (18.9) |
GLT’s total dose, in DDD | 1.50 [0.75; 2.28] | 0.75 [0.35; 1.11] | 0.71 [0.11; 1.33] | 0.85 [0.00; 2.59] | 1.50 [1.15; 2.10] | 1.14 [0.41; 1.79] | 2.28 [1.67; 2.85] |
GLT’s total dose among users, in DDD | 1.67 [0.89; 2.58] | 0.85 [0.50; 1.43] | 0.79 [0.69; 1.69] | 1.81 [0.83; 2.86] | 1.53 [1.21; 2.11] | 1.52 [0.85; 2.07] | 2.28 [1.67; 2.85] |
GLT classes | |||||||
Biguanides | |||||||
Use | 79 (53.7) | 8 (50.0) | 5 (35.7) | 9 (39.1) | 18 (62.1) | 16 (57.1) | 23 (62.2) |
DDD among users | 0.85 [0.57; 1.28] | 0.68 [0.48; 0.85] | 0.50 [0.43; 0.50] | 0.85 [0.85; 1.28] | 0.85 [0.50; 1.17] | 0.85 [0.85; 1.28] | 0.85 [0.80; 1.28] |
Insulin | |||||||
Use | 29 (19.7) | 1 (6.3) | 4 (28.6) | 3 (13.0) | 11 (37.9) | 0 (0.0) | 10 (27.0) |
DDD among users | 1.00 [0.60; 1.35] | 0.75 | 0.34 [0.31; 0.41] | 1.95 [1.40; 2.16] | 1.05 [0.73; 1.24] | NA | 1.28 [0.93; 1.46] |
OHA | |||||||
Use | 79 (53.7) | 8 (50.0) | 5 (35.7) | 10 (43.5) | 15 (51.7) | 12 (42.9) | 29 (78.4) |
DDD among users | 1.50 [1.00; 1.89] | 1.00 [0.94; 1.00] | 1.43 [1.00; 1.50] | 1.00 [0.56; 2.04] | 1.50 [0.88; 1.50] | 1.21 [0.94; 1.57] | 1.50 [1.43; 2.00] |
Hypoglycemic agents | |||||||
Use | 101 (68.7) | 9 (56.3) | 6 (42.9) | 13 (56.5) | 24 (82.8) | 12 (42.9) | 37 (100.0) |
DDD among users | 1.43 [1.00; 1.79] | 1.00 [0.75; 1.00] | 1.38 [0.81; 1.77] | 1.00 [0.75; 2.14] | 1.24 [0.97; 1.50] | 1.21 [0.94; 1.57] | 1.50 [1.35; 2.00] |