HNF1A gene p.I27L is associated with early-onset, maturity-onset diabetes of the young-like diabetes in Turkey

Table 4 HNF1A gene p.I27L SNPs and clinical features in diabetics patients

	GG (wild) n = 146	GT n = 233	TT n = 110	P^a GG/GT	P^b GG/TT	P^c GT/TT
Age at the diagnosis (year)^a	23.36 ± 9.51	20.89 ± 6.54	21.29 ± 9.78	0.845	0.653	0.958
Parent diabetes (%)	78.5	89.2	98.7	0.427	0.035	0.852
BMI (kg/m²)^a	26.78 ± 6.02	27.81 ± 3.85	28.42 ± 4.70	0.871	0.852	0.990
Fasting glucose (mg/dl)^a	151.12 ± 75.89	175.01 ± 98.35	154.01 ± 68.13	0.895	0.836	0.127
Postprandial glucose (mg/dl)^a	239.43 ± 114.53	264.18 ± 100.37	276.18 ± 125.38	0.625	0.327	0.785
HbA1c (%)	7.85 ± 3.45	8.20 ± 6.75	8.47 ± 2.29	0.427	0.324	0.913
LDL (mg/dl)^a	112.30 ± 37.61	106.09 ± 30.98	136.09 ± 45.65	0.358	0.339	0.249
TG (mg/dl)^a	174.31 ± 175.80	197.91 ± 186.34	218.91 ± 276.52	0.258	0.041	0.377
Cholesterol (mg/dl)^a	185.35 ± 96.84	189.27 ± 35.63	197.87 ± 44.90	0.957	0.924	0.847
HDL (mg/dl)^a	46.22 ± 11.37	49.32 ± 17.93	43.28 ± 20.85	0.542	0.627	0.332
C-peptide (nmol/L)^a	2.82 ± 2.28	2.15 ± 1.32	2.32 ± 1.51	0.246	0.351	0.513
Microalbuminuria	91.30 ± 357.93	96.42 ± 349.35	106.50 ± 320.85	0.792	0.650	0.838

^aGG genotype vs GT genotype ^bGG genotype vs TT genotype ^cGT genotype vs TT genotype
Data are shown as mean ± standard deviation (means ± SD) and percentage (%)
Bold represents the significant p-values
BMI body mass index, HbA1c hemoglobin A1c
Student’s t test was used for normally distributed continuous variables or log-transformed variables between two groups
Categorical variables were analyzed with the Chi-square test or Fisher’s exact test, where appropriate

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