Table 3 Preoperative serum hormones and cytological findings
From: Calcitonin negative Medullary Thyroid Carcinoma: a challenging diagnosis or a medical dilemma?
Author | CT serum levels | CEA serum | Cytological examination | Immunohistochemistry |
|---|---|---|---|---|
Sobol | Normal limits | NA | NA | NA |
Schmid 1 | NA | NA | NA | NA |
Schmid 2 | NA | NA | NA | NA |
Schmid 3 | NA | NA | NA | NA |
Schmid 4 | NA | NA | NA | NA |
Redding | 8.2 pg/mL | NA | Atypical cells not diagnostic of MTC | Positive for calcitonin |
Bockhorn | 0.8 pg/mL | Normal limits | Suspicious for MTC or anaplastic cancer | NA |
Sand | 5.3 pg/mL | NA | NA | NA |
Dora | 4.0 pg/mL | 0.78 ng/mL | Atypias suggesting for malignancy | NA |
Wang | 38 pg/mL | 56.7 ng/mL | Discohesive cells with eccentric nuclei, finely granular chromatin and relatively uniform morphology | Negative for calcitonin |
Giovanella | 4.7 pg/mL | 12.8 ng/mL | Aggregates of elonged cells with finely granular cytoplasm and oval nuclei with coarsely clumped chromatin and nuclear pseudoinclusions | Positive for calcitonin |
Alapat | 4.0 pg/mL | 1.0 ng/mL | Positive for MTC | Positive for MTC |
Chernyavsky | 2.1 pg/mL | 0.5 ng/mL | Findings suspicious for a poorly differentiated carcinoma with neuroendocrine differentiation | Negative for calcitonin |
Nakazawa | 22 pg/mL | NA | Several solid cell clusters | NA |
Frank-Raue 1 | 2.9 pg/mL | 1.3 ng/mL | Suspected malignancy | NA |
Frank-Raue 2 | ≤2 pg/mL | 2.1 ng/mL | NA | NA |
Frank-Raue 3 | < 0.8 pg/mL | 2.8 ng/mL | Positive for MTC | NA |
Frank-Raue 4 | 2.6 pg/mL | 3.1 ng/mL | NA | NA |
Frank-Raue 5 | Normal limits | Normal limits | NA | NA |
Frank-Raue 6 | 11 pg/mL | Normal limits | NA | NA |
Frank-Raue 7 | 1.5 pg/mL | 1.7 ng/mL | NA | NA |
Ismi | 5.6 pg/mL | Normal limits | NA | NA |
Brutsaert | 2.1 pg/mL | 3.1 ng/mL | Positive for malignant cells | Positive for calcitonin in isolated cells |
Kim | 3.7 pg/mL | NA | Positive for MTC | NA |
Kasajima | 29 pg/mL | NA | Positive for MTC | Negative for calcitonin |
Samà 1 | 7.8 pg/mL | NA | NA | NA |
Samà 2 | 5 pg/mL | NA | NA | NA |
Samà 3 | < 10 pg/mL | 1.8 ng/mL | NA | NA |
Samà 4 | 13 pg/mL | 6.3 ng/mL | NA | NA |
Parmer | NA | NA | Suspected malignancy | NA |
Zhou | NA | NA |