Table 4 Hazard ratios for relapse fitted with new TRAb’s 4th versus 1st-3rd quartile and into GREATa
Assay | Recommended cut-offs by the manufacturer | Level of Q4 | HR for assay alone (Q4 vs. Q1–3) (95% CI) | HR for GREAT Class II with new assay (95% CI) | HR for GREAT Class III with new assay (95% CI) |
|---|---|---|---|---|---|
BRAHMS TRAK | ≥ 1.80 U/L | ≥ 8.10 U/L | 3.53 (1.35–9.22) | 2.02 (0.64–6.36) | 3.11 (0.57–17.07) |
IMMULITE TSI | ≥ 0.55 U/L | ≥ 5.66 U/L | 3.12 (1.20–8.12) | 3.73 (0.84–16.44) | 3.01 (0.27–33.34) |
EliA anti-TSH-R | ≥ 2.90 U/L | ≥ 7.40 U/L | 4.52 (1.71–11.99) | 2.44 (0.79–7.60) | 2.37 (0.26–21.18) |
RSR TRAb Fast | ≥ 1.00 U/L | ≥ 7.21 U/L | 4.41 (1.66–11.71) | 2.47 (0.80–7.72) | 1.96 (0.22–17.62) |
RSR-bioassay STIMULATION | ≥ 150% | ≥ 711% | 3.63 (1.39–9.46) | N/A | N/A |