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Table 3 Risk factors associated with TD among patients with hepatitis C infection by univariate and multivariate Cox regression analyses

From: Long-term outcomes and risk factors of thyroid dysfunction during pegylated interferon and ribavirin treatment in patients with chronic hepatitis C infection in Taiwan

 

Univariate analysis

Multivariate analysis

Variables

Hazard ratio (95% CI)

P-value

Hazard ratio (95% CI)

P value

Sex (F/M)

1.46 (1.19–1.78)

< 0.001

1.49 (1.23–1.75)

< 0.001

PEG-IFN/RBV treatment (yes/no)

1.70 (1.40–2.07)

< 0.001

1.68 (1.38–2.06)

< 0.001

Hyperlipidemia (yes/no)

141 (1.16–1.72)

< 0.001

1.38 (1.12–1.71)

< 0.001

Past history of goiter (yes/no)

6.61 (5.18–8.43)

< 0.001

6.40 (5.00–8.18)

< 0.001

  1. TD thyroid dysfunction, HR hazard ratio, CI confidence interval, M males, F females, PEG-IFN/RBV pegylated interferon/ribavirin, CKD chronic kidney disease
  2. The dependent variable was thyroid dysfunction (yes/no). The available independent variables were age, sex, PEG-IFN/RBV treatment, hyperlipidemia, regional residence, hypertension, CKD, diabetes mellitus, liver cirrhosis, past history of goiter