Association between random glucose and all-cause mortality: findings from the mortality follow-up of the German National Health Interview and Examination Survey 1998

Table 3 Sensitivity analyses for risk for all-cause mortality (HR (95% CI)) by random glucose categories

	Random glucose category (in mmol/L)
Model	< 4.3	4.3 - < 5.3	5.3 - < 5.8	5.8 - < 6.8	6.8 - < 7.8	7.8 - < 11.1	≥ 11.1
a) adjusted for fasting time^a	1.96 (0.87–4.43)	ref.	1.16 (0.89–1.51)	1.22 (0.92–1.60)	1.46 (0.89–2.39)	2.10 (1.28–3.42)	4.99 (2.33–10.73)
b) excluding fasting time < 2 h^b	2.07 (0.85–5.03)	ref.	1.14 (0.87–1.50)	1.18 (0.89–1.57)	1.43 (0.85–2.41)	2.20 (1.25–3.86)	4.38 (2.01–9.58)
c) adjusted for HbA_1c^c	1.96 (0.86–4.44)	ref.	1.17 (0.90–1.51)	1.21 (0.91–1.60)	1.35 (0.83–2.20)	1.82 (1.09–3.03)	3.46 (1.49–8.04)
d) excluding HbA_1c ≥ 6.5%^d	1.73 (0.73–4.09)	ref.	1.12 (0.85–1.48)	1.23 (0.92–1.63)	1.08 (0.54–2.13)	2.46 (1.50–4.03)	–
e) excluding FU time ≤ 2 years^e	2.10 (0.87–5.06)	ref.	1.12 (0.85–1.46)	1.11 (0.82–1.48)	1.30 (0.77–2.19)	1.97 (1.21–3.21)	3.72 (1.51–9.19)
f) multiple imputation^f	1.68 (0.92–3.07)	ref.	1.12 (0.88–1.41)	1.25 (0.98–1.59)	1.81 (1.17–2.80)	1.94 (1.26–3.01)	2.96 (1.48–5.92)

Models with adjustment as in model 4 with additional adjustment for fasting time in a) and HbA _1c in c)
^a fasting time with five categories (< 2, 2 - < 4, 4 - < 8, 8 - < 12 and ≥ 12 h)
^b n = 5579 (428 cases, 5151 non-cases)
^c HbA _1c with five categories (< 5.0, 5.0- < 5.7, 5.7- < 6.5, ≥ 6.5%)
^d n = 5718 (386 cases, 5332 non-cases), no participant with random glucose ≥ 11.1 mmol/L
^e n = 5912 (415 cases, 5497 non-cases)
f n = 6570 (551 cases, 6061 non-cases, 138 missings), missings were replaced in the source population using multiple imputation by fully conditional specification

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