The ratio of AGE to sRAGE independently associated with albuminuria in hypertensive patients

BMC Endocrine Disorders

Table 2 Univariate and multivariate analysis for associated factors of albuminuria by logistic regression model with forward stepwise method

		Univariate		Multivariate
		OR (95% CI)	P	OR (95% CI)	P
Age (year)		1.002 (0.97–1.035)	0.191
Gender	Male	–	–
Gender	Female	0.936 (0.387–2.262)	0.883
Smoking	Not smoker	–	–
	Past smoker	0.915 (0.303–2.765)	0.875
	Current smoker	0.677 (0.168–2.730)	0.584
Body mass index		1.046 (0.909–1.202)	0.531
Heart rate (/min)		1.001 (0.970–1.034)	0.928
Systolic blood pressure (mmHg)		1.034 (1.010–1.059)	0.006
Diastolic blood pressure (mmHg)		1.040 (1.006–1.076)	0.022
Pulse pressure (mmHg)		1.040 (1.002–1.079)	0.038	1.020 (0.979–1.062)	0.350
Number of drugs		1.775 (1.074–2.934)	0.025	1.986 (1.082–3.645)	0.027
Impaired fasting glucose		1.206 (0.516–2.822)	0.665
Laboratory
Total cholesterol (mg/dl)		1.003 (0.991–1.016)	0.607
Triglycerides (mg/dL)		1.001 (0.998–1.005)	0.541
HDL (mg/dL)		1.002 (0.958–1.048)	0.927
LDL (mg/dL)		1.001 (0.988–1.014)	0.933
Fasting glucose (mg/dL)		1.002 (0.966–1.039)	0.931
ALT (U/L)		0.979 (0.913–1.048)	0.538
AST (U/L)		1.113 (0.998–1.241)	0.055	1.095 (0.962–1.246)	0.169
Uric acid (mg/dL)		1.220 (0.921–1.616)	0.166
eCCr (mL/min)		0.989 (0.973–1.004)	0.149
hs-CRP (mg/dL)		1.227 (0.501–3.002)	0.654
Adiponectin (μg/mL)		0.994 (0.973–1.017)	0.622
ADMA (μmol/L)		1.575 (0.003–732.211)	0.885
NT-proBNP (pg/mL)		1.011 (1.000–1.022)	0.049	1.015 (1.001–1.030)	0.030
AGE (μg/mL)		1.208 (0.838–1.741)	0.311
sRAGE (pg/ml)		0.999 (0.996–1.001)	0.189
AGE/sRAGE (μg/pg)		1.109 (1.005–1.224)	0.039	1.131 (1.001–1.278)	0.048

Abbreviation: ARB angiotensin II receptor blocker, ACEI angiotensin-converting enzyme inhibitor, HDL high-density lipoprotein; LDL low-density lipoprotein; alanine aminotransferase, eCCr estimated creatinine clearance rate, hs-CRP high-sensitivity C-reactive protein, ADMA asymmetric dimethylarginine, NT-proBNP N-terminal pro-brain natriuretic peptide, AGE advanced glycation end product, sRAGE soluble form of receptor for AGE, AGE/sRAGE ratio of levels of AGE to soluble form of RAGE

ISSN: 1472-6823