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Table 3 Adverse pregnancy outcomes according to maternal TSH concentration in the first trimester

From: Effect of mildly elevated thyroid-stimulating hormone during the first trimester on adverse pregnancy outcomes

Pregnancy outcomes Normal (n = 1532), n (%) eTSH (2.5–4 mIU/L) (n = 142), n (%) χ2 P
Mother
 IUGR 12 (0.8) 1 (0.7) 0.00 1.00
 GDM 163 (10.6) 12 (8.5) 0.67 0.42
 Gestational hypertension/preeclampsia 25 (1.6) 1 (0.7) 0.25 0.62
 PROM 394 (25.7) 30 (21.1) 1.45 0.23
 Placental abruption 14 (0.9) 1 (0.7) 0.00 1.00
 Placenta previa 15 (1.0) 0 (0.0) 0.52 0.47
 Premature delivery (< 37 weeks) 60 (3.9) 3 (2.1) 0.72 0.40
 PPH 50 (3.3) 5 (3.5) 0.03 0.87
 Delivery method (assisted vaginal delivery or cesarean section) 95 (25.9) 7 (23.3) 0.10 0.76
Newborn
 LBW 38 (2.5) 4 (2.8) 0.00 1.00
 SGA 36 (2.3) 3 (2.1) 0.00 1.00
 LGA 236 (15.4) 21 (14.8) 0.04 0.84
 Apgar score ≤ 7 at 1 or 5 min 27 (1.8) 0 (0.0) 1.55 0.21
  1. TSH thyroid-stimulating hormone, eTSH elevated thyroid-stimulating hormone, IUGR intrauterine growth restriction, GDM gestational diabetes mellitus, PROM premature rupture of membranes, PPH postpartum hemorrhage, LBW low birth weight, SGA small for gestational age, LGA large for gestational age