Table 3 Changes in CGM glycaemic indices from baseline between low dose or high dose BTI320 and placebo using random effect models with repeated measurements adjusted for intra-individual between-meal and between meal-day variability
CGM Parameter | Low Dose BTI320 | High Dose BTI320 | ||
|---|---|---|---|---|
Mean Difference (95% CI) | p | Mean Difference (95% CI) | p | |
AUCpp at 1 h | −0.30 (− 0.48, − 0.11) | < 0.01 | −0.14 (− 0.32, 0.04) | 0.13 |
AUCpp at 2 h | −0.59 (− 1.01, − 0.18) | 0.01 | −0.17 (− 0.57, 0.24) | 0.42 |
AUCpp at 3 h | −0.74 (− 1.35, − 0.14) | 0.02 | −0.17 (− 0.75, 0.42) | 0.57 |
MPMG | −0.42 (− 0.81, − 0.03) | 0.03 | −0.09 (− 0.48, 0.29) | 0.63 |
SD at 1 h | −0.05 (− 0.13, 0.02) | 0.18 | 0.01 (− 0.06, 0.09) | 0.73 |
SD at 2 h | −0.07 (− 0.15, 0.00) | 0.06 | 0.03 (− 0.05, 0.10) | 0.46 |
SD at 3 h | −0.07 (− 0.15, 0.00) | 0.06 | 0.03 (− 0.05, 0.10) | 0.46 |
% CV at 1 h | −0.48 (− 1.46, 0.50) | 0.34 | 0.22 (− 0.73, 1.18) | 0.64 |
% CV at 2 h | −0.62 (− 1.50, 0.26) | 0.17 | 0.39 (− 0.46, 1.24) | 0.37 |
% CV at 3 h | −0.65 (− 1.62, 0.31) | 0.18 | 0.42 (− 0.51, 1.36) | 0.37 |