Association between thyroid hormones and the components of metabolic syndrome

Jang, Jieun; Kim, Youngsook; Shin, Jaeyong; Lee, Sang Ah; Choi, Young; Park, Eun-Cheol

doi:10.1186/s12902-018-0256-0

BMC Endocrine Disorders

Table 2 The estimates for the components of metabolic syndromes^a

From: Association between thyroid hormones and the components of metabolic syndrome

Variable	Waist circumference (inches)			Triglycerides (mg/dL)			HDL cholesterol (mg/dL)			Blood pressure (mmHg)			Fasting glucose (mg/dL)
Variable	β^a	S.E	p-value	β^a	S.E	p-value	β^a	S.E	p-value	β^a	S.E	p-value	β^a	S.E	p-value
Free thyroxine hormone (ng/dL)
Low (< 0.80)	1.383	0.938	0.1407	38.690	30.172	0.2000	−0.267	3.109	0.9317	0.758	3.532	0.8301	2.727	4.217	0.5180
Normal (low tertile) (< 1.17)	0.327	0.240	0.1731	9.957	7.705	0.1964	−0.279	0.801	0.7272	−0.712	0.905	0.4313	1.698	1.077	0.1152
Normal (mid tertile) (< 1.31)	Ref.			Ref.			Ref.			Ref.			Ref.
Normal (high tertile) (< 1.70)	− 0.426	0.236	0.0714	−21.145	7.591	0.0054	1.439	0.788	0.0681	−0.359	0.890	0.6869	0.268	1.061	0.8003
High (1.70≤)	−0.735	0.753	0.3292	−49.713	24.227	0.0404	−1.718	2.603	0.5095	2.068	2.836	0.4661	15.992	3.386	<.0001
Thyroid stimulating hormone (uIU/mL)
Low (< 0.50)	−1.253	0.673	0.0629	−20.614	21.742	0.3432	4.393	2.227	0.0487	2.656	2.569	0.3014	0.178	3.040	0.9533
Normal (low tertile) (< 1.80)	−0.318	0.234	0.1742	0.479	7.559	0.9495	−0.558	0.783	0.4759	0.630	0.880	0.4743	1.680	1.057	0.1122
Normal (mid tertile) (< 2.87)	Ref.			Ref.			Ref.			Ref.			Ref.
Normal (high tertile) (< 5.00)	− 0.378	0.257	0.1414	3.591	8.297	0.6652	0.035	0.859	0.9671	1.283	0.966	0.1843	0.713	1.160	0.5392
High (5.00≤)	−0.093	0.374	0.8044	9.045	12.095	0.4547	−0.890	1.246	0.4748	0.660	1.406	0.6389	−1.511	1.691	0.3717
Thyroid peroxidase antibody (IU/mL)^b
Normal (< 34)	Ref.			Ref.			Ref.			Ref.			Ref.
High (under low FT4) (34≤)	0.396	0.498	0.4268	36.075	16.046	0.0247	−2.475	1.674	0.1396	−0.814	1.866	0.6626	−2.152	2.249	0.3387
High (under high FT4) (34≤)	−0.620	0.556	0.2655	−6.054	17.922	0.7356	0.118	1.862	0.9493	4.319	2.084	0.0384	−1.604	2.512	0.5232
Thyroid peroxidase antibody (IU/mL)^c
Normal (< 34)	Ref.			Ref.			Ref.			Ref.			Ref.
High (under low TSH) (34≤)	−0.307	0.587	0.6014	−5.248	18.895	0.7812	−1.617	1.966	0.4110	−0.493	2.198	0.8225	−1.511	2.648	0.5682
High (under high TSH) (34≤)	0.111	0.478	0.8162	32.181	15.396	0.0368	−1.130	1.608	0.4825	2.723	1.791	0.1288	−2.169	2.157	0.3149

^aModels is adjusted by age, gender, education level, marital status, household income level, region, occupation, alcohol consumption, smoking, walking activity and stress level
^bConsidering that thyroid peroxidase antibody related to both hypothyroidism and hyperthyroidism, high groups were divided into two groups by two median of free thyroxine
^cConsidering that thyroid peroxidase antibody related to both hypothyroidism and hyperthyroidism, high groups were divided into two groups by two median of thyroid stimulating hormone

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