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Fig. 3 | BMC Endocrine Disorders

Fig. 3

From: ATR-101, a selective ACAT1 inhibitor, decreases ACTH-stimulated cortisol concentrations in dogs with naturally occurring Cushing’s syndrome

Fig. 3

Histologic approach used to evaluate adrenal tissue in dogs with adrenal-dependent Cushing’s syndrome treated with ATR-101. (a) H&E stained adrenal tissue demonstrating proliferative neoplastic adrenocortical cells arranged in packets separated by fine fibrovascular stroma in a dog with adrenocortical carcinoma (40×, bar = 60 μm); (b) strong nuclear immunoreactivity for caspase-3 indicating increased cellular apoptotic activity (Vector red chromogen, 40×); positive cytoplasmic immunolabeling for Melan-A (Vector red chromogen, 40×) (c) and inhibin (diaminobenzidine chromogen, brown, 40×) (d) confirming adrenocortical origin

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BMC Endocrine Disorders

ISSN: 1472-6823

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