Table 1 Baseline Demographics

Age (median, IQR)

43 (21.8)

46 (17)

39 (18) p = 0.216

Gender

M: n = 29

M: n = 15

M: n = 7

F: n = 33

F: n = 14

F: n = 11

Weight (median, IQR)

78.1 kg (32.3)

83 kg (34.0)

74.2 kg (23.6) p = 0.220

#months to endo referral (median, IQR)

20 (16)

24 (13)

15 (20) p = 0.317

TBI Severity

Mild n = 48

Mild n = 22

Mild n = 17

Mod n = 6

Mod n = 1

Mod n = 1

Severe n = 8

Severe n = 6

Documented Sport Concussion

n = 15

n = 7

n = 5

Hockey n = 4

Hockey n = 3

Basketball n = 1

Cycling n = 2

Cycling n = 2

Dirt biking n = 1

Basketball n = 2

Basketball n = 1

Football n = 1

Soccer n = 2

Football n = 1

Equestrian n = 1

Football n = 2

Soccer n = 1

Dirt biking n = 1

Wrestling n = 1

Equestrian n = 1

Documented pituitary deficits

n = 4

n = 2

n = 1

n = 1 secondary hypothyroidism

n = 1 secondary hypothyroidism

n = 1 secondary hypogonadism and hypothyroidism

n = 2 secondary hypogonadism

n = 1 secondary hypogonadism

n = 1 secondary hypothyroidism and secondary hypogonadism

IGF-1 Z score (median, IQR)

−0.193 (2.07)

−0.214 (1.52)

−0.060 (1.24) p = 0.979

Peak GH during stim test (median, IQR)

3.8 μg/L (6.9)

1.3 μg/L (2.6)

9.7 μg/L (4.3) p = < 0.001