Associations between ERα/β gene polymorphisms and osteoporosis susceptibility and bone mineral density in postmenopausal women: a systematic review and meta-analysis

Zhu, Heping; Jiang, Jiannong; Wang, Qiang; Zong, Jun; Zhang, Liang; Ma, Tieliang; Xu, Youjia; Zhang, Leiyan

doi:10.1186/s12902-018-0230-x

Table 3 Characteristics of included studies of lumbar spine BMD, femoral neck BMD, lumbar spine Z value and femoral neck Z value in ERα PvuII genotypes

From: Associations between ERα/β gene polymorphisms and osteoporosis susceptibility and bone mineral density in postmenopausal women: a systematic review and meta-analysis

ERα PvuII			Lumbar Spine BMD (g/cm²)						ERα PvuII			Femoral Neck BMD (g/cm²)
ERα PvuII			PP		Pp		pp		ERα PvuII			PP		Pp		pp
Author	Year	Ethnicity	N	Mean ± SD	N	Mean ± SD	N	Mean ± SD	Author	Year	Ethnicity	N	Mean ± SD	N	Mean ± SD	N	Mean ± SD
Ivanova et al.	2007	Caucasian	58	0.70 ± 0.09	110	0.71 ± 0.10	52	0.77 ± 0.06	Ivanova et al.	2007	Caucasian	58	0.52 ± 0.02	110	0.68 ± 0.01	52	0.76 ± 0.05
Albagha et al.	2001	Caucasian	37	0.87 ± 0.03	102	0.86 ± 0.02	67	0.88 ± 0.02	Albagha et al.	2001	Caucasian	37	0.75 ± 0.02	102	0.71 ± 0.01	67	0.75 ± 0.02
Aerssens et al.	2000	Caucasian	27	0.93 ± 0.18	66	0.91 ± 0.22	42	0.89 ± 0.17	Aerssens et al.	2000	Caucasian	27	0.69 ± 0.06	66	0.70 ± 0.09	42	0.69 ± 0.11
Jeedigunta et al.	2010	Asian	50	0.92 ± 0.18	81	0.89 ± 0.11	116	0.81 ± 0.14	Kurt et al.	2012	Caucasian	44	0.77 ± 0.08	104	0.81 ± 0.09	46	0.82 ± 0.09
Kurt et al.	2012	Caucasian	44	0.93 ± 0.13	104	0.93 ± 0.11	46	0.93 ± 0.09	Ge et al.	2006	Asian	38	0.68 ± 0.09	93	0.67 ± 0.07	67	0.69 ± 0.08
Kurabayashi et al.	1999	Asian	19	0.99 ± 0.04	27	0.89 ± 0.03	36	0.91 ± 0.02	Ge et al.	2006	Asian	38	0.68 ± 0.09	92	0.67 ± 0.08	67	0.69 ± 0.08
Ge et al.	2006	Asian	38	0.73 ± 0.10	93	0.74 ± 0.09	67	0.75 ± 0.10	Qin et al.	2004	Asian	40	0.57 ± 0.01	113	0.60 ± 0.01	91	0.59 ± 0.01
Ge et al.	2006	Asian	38	0.73 ± 0.10	92	0.74 ± 0.09	67	0.75 ± 0.10	Pérez et al.	2008	Caucasian	9	0.59 ± 0.01	37	0.57 ± 0.01	16	0.57 ± 0.02
Qin et al.	2004	Asian	40	0.70 ± 0.01	113	0.70 ± 0.01	91	0.72 ± 0.01
Pérez et al.	2008	Caucasian	11	0.73 ± 0.03	34	0.66 ± 0.02	17	0.65 ± 0.02
ERα PvuII			Lumbar Spine Z value						ERα PvuII			Femoral Neck Z value
ERα PvuII			PP		Pp		pp		ERα PvuII			PP		Pp		pp
Author	Year	Ethnicity	N	Mean ± SD	N	Mean ± SD	N	Mean ± SD	Author	Year	Ethnicity	N	Mean ± SD	N	Mean ± SD	N	Mean ± SD
Shang et al.	2016	Asian	28	−1.54 ± 0.35	100	−1.67 ± 0.91	70	−2.79 ± 1.46	Ivanova et al.	2007	Caucasian	58	−2.00 ± 0.00	110	−1.90 ± 0.00	52	−0.70 ± 0.00
Ivanova et al.	2007	Caucasian	58	−2.40 ± 0.00	110	−2.10 ± 0.00	52	−1.50 ± 0.00	Albagha et al.	2001	Caucasian	37	−0.29 ± 0.17	102	−0.59 ± 0.09	67	−0.28 ± 0.15
Albagha et al.	2001	Caucasian	37	−0.35 ± 0.16	102	−0.44 ± 0.10	67	−0.28 ± 0.14	An et al.	2000	Asian	53	−0.48 ± 0.90	128	−0.19 ± 0.80	128	0.31 ± 0.49
An et al.	2000	Asian	53	−0.53 ± 0.16	128	−0.21 ± 0.99	65	0.22 ± 0.46

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