Associations between ERα/β gene polymorphisms and osteoporosis susceptibility and bone mineral density in postmenopausal women: a systematic review and meta-analysis

Zhu, Heping; Jiang, Jiannong; Wang, Qiang; Zong, Jun; Zhang, Liang; Ma, Tieliang; Xu, Youjia; Zhang, Leiyan

doi:10.1186/s12902-018-0230-x

Table 1 General characteristics of studies assciated with postmenopausal osteoporosis risk

From: Associations between ERα/β gene polymorphisms and osteoporosis susceptibility and bone mineral density in postmenopausal women: a systematic review and meta-analysis

Author	Year	Ethnicity	Sample Size		ERα XbaI										HWE
			Sample Size		Case					Control
			Case	Control	X	x	XX	Xx	xx	X	x	XX	Xx	xx
Shang et al.	2016	Asian	198	276	338	58	146	46	6	109	443	10	89	177	0.77
Wang et al.	2015	Asian	72	72	125	19	55	15	2	132	12	62	8	2	0.21
Li et al.	2014	Asian	440	791	254	626	31	192	217	404	1178	48	308	435	0.50
Erdogan et al.	2011	Caucasian	50	30	41	59	7	27	16	28	32	6	16	8	0.70
Jeedigunta et al.	2010	Asian	247	254	253	241	60	133	54	306	202	81	144	29	0.32
Tanriover et al.	2010	Caucasian	50	50	48	52	5	38	7	54	46	12	30	8	0.14
Harsløf et al.	2010	Caucasian	228	225	134	322	19	96	113	164	286	30	104	91	0.97
Musumeci et al.	2009	Caucasian	100	200	130	70	35	60	5	155	245	13	129	58	0.26
Pérez et al.	2008	Caucasian	64	68	48	80	9	30	25	46	90	5	36	27	0.13
Ivanova et al.	2007	Caucasian	220	180	256	184	73	110	37	163	197	25	113	42	0.58
Huang et al.	2006	Asian	66	116	19	113	2	15	49	46	186	4	38	74	0.74
Nam et al.	2005	Asian	6	168	0	12	0	0	6	63	273	6	51	111	0.96
Qin et al.	2004	Asian	244	273	120	368	11	98	135	137	409	13	111	149	0.18
Aerssens et al.	2000	Caucasian	135	239	92	178	14	64	57	175	303	32	111	96	0.99
Author	Year	Ethnicity	Sample Size		ERα PvuII										HWE
			Sample Size		Case					Control
			Case	Control	P	p	PP	Pp	pp	P	p	PP	Pp	pp
Shang et al.	2016	Asian	198	276	156	240	28	100	70	386	166	138	110	28	0.38
Wang et al.	2015	Asian	60	60	30	90	3	24	33	32	88	3	26	31	0.40
Li et al.	2014	Asian	440	791	368	512	65	238	137	498	1084	69	360	362	0.12
Sonoda et al.	2012	Asian	114	171	118	110	24	70	20	137	205	31	75	65	0.26
Erdogan et al.	2011	Caucasian	50	30	42	58	8	26	16	38	22	10	18	2	0.11
Jeedigunta et al.	2010	Asian	247	254	181	313	50	81	116	232	276	60	112	82	0.08
Tanriover et al.	2010	Caucasian	50	50	39	61	7	25	18	48	52	14	20	16	0.79
Harsløf et al.	2010	Caucasian	228	224	198	258	46	106	76	233	215	63	107	54	0.52
Musumeci et al.	2009	Caucasian	100	200	120	80	30	60	10	186	214	31	124	45	0.53
Pérez et al.	2008	Caucasian	64	68	56	72	11	34	19	58	78	12	34	22	0.86
Ivanova et al.	2007	Caucasian	220	180	226	214	58	110	52	148	212	21	106	53	0.37
Morón et al.	2006	Caucasian	87	175	79	95	17	45	25	171	179	45	81	49	0.33
Huang et al.	2006	Asian	66	116	79	53	23	33	10	68	164	11	46	59	0.64
Nam et al.	2005	Asian	6	168	2	10	1	0	5	130	206	25	80	63	0.96
Qin et al.	2004	Asian	244	273	193	295	40	113	91	223	323	43	137	93	0.52
Aerssens et al.	2000	Caucasian	135	239	120	150	27	66	42	219	259	47	125	67	0.41
Author	Year	Ethnicity	Sample Size		ERα G2014A										HWE
			Sample Size		Case					Control
			Case	Control	A	G	AA	GA	GG	A	G	AA	GA	GG
Wajanavisit et al.	2015	Asian	99	113	94	104	33	28	38	179	47	72	35	6	0.53
Gómez et al.	2007	Caucasian	70	500	30	110	2	26	42	303	697	40	223	237	0.21
Ongphiphadhanakul et al.	2003	Asian	33	325	23	43	5	13	15	129	521	13	103	209	0.94
Ongphiphadhanakul et al.	2001	Asian	106	122	56	156	8	40	58	37	207	2	33	87	0.57
Author	Year	Ethnicity	Sample Size		ERβ AluI										HWE
			Sample Size		Case					Control
			Case	Control	A	G	AA	GA	GG	A	G	AA	GA	GG
Shoukry et al.	2015	Caucasian	200	180	223	177	75	73	52	125	235	30	65	85	0.46
Huang et al.	2015	Asian	413	890	678	148	285	108	20	1384	396	541	302	47	0.57
Harsløf et al.	2010	Caucasian	228	224	154	302	26	102	100	186	262	35	116	73	0.32
Morón et al.	2006	Caucasian	88	177	76	100	11	54	23	146	208	34	78	65	0.23
Author	Year	Ethnicity	Sample Size		ERβ RsaI										HWE
			Sample Size		Case					Control
			Case	Control	A	G	AA	GA	GG	A	G	AA	GA	GG
Shoukry et al.	2015	Caucasian	200	180	52	348	2	48	150	37	323	1	35	144	0.47
Huang et al.	2015	Asian	413	777	329	497	63	203	147	759	795	169	421	187	0.28

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