Table 2 Clinical factors which may affect HbA1c reduction after treatment with short-acting exenatide over 20 weeks
HbA1c reduction ≥0.6% | HbA1c <7.5% | HbA1c reduction ≥9.8% from baseline | |||||||
|---|---|---|---|---|---|---|---|---|---|
Yes (n = 316) | No (n = 303) | P | Yes (n = 346) | No (n = 273) | P | Yes (n = 263) | No (n = 356) | P | |
Age (years) | |||||||||
≥ 50 | 24.4 (151) | 24.9 (154) | 0.45 | 27.1 (168) | 22.1 (137) | 0.69 | 20.0 (124) | 29.2 (181) | 0.36 |
< 50 | 26.7 (165) | 24.1 (149) | 28.8 (178) | 22.0 (136) | 22.5 (139) | 28.3 (175) | |||
Sex (%) | |||||||||
Male | 19.9 (123) | 13.6 (84) | 0.003 | 19.7 (122) | 13.7 (85) | 0.28 | 17.3 (107) | 16.2 (100) | 0.001 |
Female | 31.2 (193) | 35.4 (219) | 36.2 (224) | 30.4 (188) | 25.2 (156) | 41.4 (256) | |||
BMI (kg/m2) | |||||||||
≥ 30 | 31.6 (184) | 27.2 (158) | 0.13 | 32.8 (191) | 26.0 (151) | 0.69 | 25.8 (150) | 33.0 (192) | 0.41 |
< 30 | 19.6 (114) | 21.7 (126) | 23.7 (138) | 17.5 (102) | 16.7 (97) | 24.6 (143) | |||
HbA1c (%) | |||||||||
≥ 8.5 | 30.7 (190) | 13.6 (84) | <0.001 | 12.1 (75) | 32.2 (199) | <0.001 | 25.5 (158) | 18.7 (116) | <0.001 |
< 8.5 | 20.4 (126) | 35.4 (219) | 43.8 (271) | 12.0 (74) | 17.0 (105) | 38.8 (240) | |||
FPG (mg/dL) | |||||||||
≥ 160 | 27.9 (137) | 15.0 (74) | <0.001 | 17.1 (84) | 25.8 (127) | <0.001 | 23.0 (113) | 19.9 (98) | <0.001 |
< 160 | 23.6 (116) | 33.5 (165) | 41.1 (202) | 16.1 (79) | 19.7 (97) | 37.4 (184) | |||
Daily dose of exenatide (μg/day) | |||||||||
≥ 15 | 36.5 (226) | 33.9 (210) | 0.55 | 39.6 (245) | 13.3 (82) | 0.82 | 31.3 (194) | 39.1 (242) | 0.12 |
< 15 | 14.5 (90) | 15.0 (93) | 16.3 (101) | 30.9 (191) | 11.2 (69) | 18.4 (114) | |||
Family history of diabetes (%) | |||||||||
No | 28.4 (135) | 24.2 (115) | 0.96 | 29.1 (138) | 23.6 (112) | 0.86 | 23.6 (112) | 29.1 (138) | 0.68 |
Yes | 25.5 (121) | 21.9 (104) | 26.5 (126) | 20.8 (99) | 22.1 (105) | 25.3 (120) | |||
Duration of diabetes (years) | |||||||||
≥ 5 | 29.4 (158) | 32.0 (172) | 0.040 | 26.3 (141) | 35.2 (189) | <0.001 | 23.8 (128) | 37.6 (202) | 0.023 |
< 5 | 22.0 (118) | 16.6 (89) | 26.8 (144) | 11.7 (63) | 18.8 (101) | 19.7 (106) | |||
Concurrent disease (%) | |||||||||
No | 6.8 (42) | 6.5 (40) | 0.97 | 7.9 (49) | 5.3 (33) | 0.45 | 5.8 (36) | 7.4 (46) | 0.78 |
Yes | 44.3 (274) | 42.5 (263) | 48.0 (297) | 38.8 (240) | 36.7 (227) | 50.1 (310) | |||
Number of previous antidiabetic medication (%) | |||||||||
0 or 1 | 15.5 (96) | 19.1 (118) | 0.025 | 24.2 (150) | 10.3 (64) | <0.001 | 12.8 (79) | 21.8 (135) | 0.042 |
2 | 35.5 (220) | 29.9 (185) | 31.7 (196) | 33.8 (209) | 29.7 (184) | 35.7 (221) | |||
Other concomitant medication (%) | |||||||||
No | 3.7 (23) | 5.2 (32) | 0.15 | 5.3 (33) | 3.6 (22) | 0.52 | 3.4 (21) | 5.5 (34) | 0.50 |
Yes | 47.3 (293) | 43.8 (271) | 50.6 (313) | 40.6 (251) | 39.1 (242) | 52.0 (322) | |||