Table 3 Surgical remission rates of patients with macroadenoma according to the Knosp grade
Preoperative medical therapy | Primary surgery | P | ||
|---|---|---|---|---|
Remission rate for GH | Total (%) | 38/67 (56.7) | 68/135 (50.4) | 0.40 |
Knosp grade 0 (%) | 15/21 (71.4) | 37/49 (75.5) | 0.72 | |
Knosp grade 1–3 (%) | 22/39 (56.4) | 31/83 (37.3) | 0.048 | |
Knosp grade 4 (%) | 1/7 (14.3) | 0/3 (0) | ~1.00 | |
Remission rate for IGF-1a | Total (%) | 25/65 (38.5) | 42/125 (33.6) | 0.51 |
Knosp grade 0 (%) | 8/21 (38.1) | 29/48 (60.4) | 0.09 | |
Knosp grade 1–3 (%) | 16/37 (43.2) | 13/74 (17.6) | 0.004 | |
Knosp grade 4 (%) | 1/7 (14.3) | 0/3 (0) | ~1.00 |