Multihormonal pituitary adenoma concomitant with Pit-1 and Tpit lineage cells causing acromegaly associated with subclinical Cushing’s disease: a case report

Table 3 Summary of past reports related to GH and ACTH double secretion pituitary tumor

Reference	Case	GH	ACTH	Analysis	Cause of ACTH and GH hypersecretion
1991 Arita et al. [6]	29 y.o. female	GHoma	SCD	Electron microscope	Bimorphous tumor (heterogeneous)
1994 R. L. Apel et al. [13]	76 y.o. female	GHoma	SCA	Electron microscope	Bimorphous tumor (heterogeneous)
1998 K. Kovacs et al. [14]	62 y.o. male	GHoma	N.D.	Electron microscope ISH	Bimorphous tumor (heterogeneous)
2001 N. Mazarakis et al. [15]	53 y.o. male	GHoma	SCA	IHC	ACTH: hyperplasia
2002 Kageyama et al. [4]	45 y.o. female	GHoma	CD	IHC	Bimorphous tumor (heterogeneous)
2002 Tahara et al. [7]	53 y.o. female	Subclinical GHoma	CD	IHC ISH	The same cell (double producer)
2006 Tsuchiya et al. [16]	54 y.o. male	GHoma	SCD	IHC	N.D.
2009 Oki et al. [17]	36 y.o. male	GHoma	SCD (HMW ACTH)	IHC	N.D.
Our case	45 y.o.male	GHoma	SCD	IHC in vitro	Bimorphous tumor (heterogeneous)

Abbreviations as follows: Ghoma GH producing adenoma, SCD Subclinical Cushing disease, CD Cushing disease, SCA silent corticotroph adenoma, HMW high molecular weight, ISH in situ hybridization, IHC immunohistochemistry, and N.D. not determined

ISSN: 1472-6823