Diabetes screening intervals based on risk stratification

BMC Endocrine Disorders

Table 3 Signal and noise of HbA1c, time when signal > noise (years) by risk group

Age category	Stratification		HbA1c signal change per year (%)^a	HbA1c noise (%)^a	Time when Signal > Noise
30–44	BMI	Underweight	0.02	0.18	10.5
		Normal	0.03	0.18	6.7
		Overweight	0.05	0.22	4.5
		Obese	0.13	0.30	2.4
	Framingham Risk Score	0–10%	0.03	0.19	6.1
		10–20%	0.11	0.23	2.1
		Over 20%	0.10	0.20	2.0
45–59	BMI	Underweight	0.02	0.18	10.4
		Normal	0.03	0.18	6.3
		Overweight	0.05	0.22	4.5
		obese	0.08	0.31	4.1
	Framingham Risk Score	0–10%	0.03	0.18	6.0
		10–20%	0.04	0.21	5.5
		Over 20%	0.06	0.25	4.1
60–74	BMI	Underweight	0.03	0.17	6.6
		Normal	0.03	0.18	7.2
		overweight	0.04	0.21	5.0
		Obese	0.06	0.23	3.9
	Framingham Risk Score	0–10%	0.02	0.17	8.0
		10–20%	0.03	0.19	6.7
		Over 20%	0.04	0.21	5.3

^aSignal defined as variance of random slope; noise defined as variance of residual between model-generated and observed HbA1c. Values represent square root of above measures to obtain HbA1c as %

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