Table 1 Characteristics of the girls with early puberty at presentation
From: Familial early puberty: presentation and inheritance pattern in 139 families
PP (n = 68) | AP (n = 48) | Total (n = 116) | ||||
|---|---|---|---|---|---|---|
n | m ± SD | n | m ± SD | n | m ± SD | |
Age at onset, years | 66 | 6.5 ± 1.8 | 48 | 8.6 ± 0.6 | 114 | 7.4 ± 1.8 |
Age at evaluation, years | 66 | 7.4 ± 1.9 | 47 | 9.4 ± 1.1 | 113 | 8.2 ± 1.9 |
Height, SDS | 65 | 2.1 ± 1.3 | 47 | 1.2 ± 1.6 | 112 | 1.7 ± 1.5 |
BMI, SDS | 65 | 1.1 ± 1.2 | 47 | 0.7 ± 1.5 | 112 | 0.9 ± 1.4 |
BA advance, years | 61 | 1.2 ± 1.1 | 36 | 0.7 ± 1.4 | 97 | 1 ± 1.2 |
Tanner breast | 66 | 2.7 ± 0.7 | 44 | 2.8 ± 0.9 | 110 | 2.8 ± 0.9 |
Tanner pubic hair | 65 | 2.1 ± 1.1 | 42 | 2.4 ± 1.1 | 107 | 2.3 ± 1.1 |
Age at M mothers, years | 66 | 11.7 ± 1.5 | 47 | 11.4 ± 1.6 | 113 | 11.6 ± 1.5 |
Age at M, years | 12 | 10.9 ± 1.8 | 12 | 10.7 ± 2 | 24 | 10.8 ± 1.9 |
Uterus length, mm | 50 | 36.5 ± 9 | 34 | 37.2 ± 11.5 | 84 | 36.8 ± 10 |
LH peak, IU/L | 63 | 12.2 ± 18.7 | 33 | 12 ± 11.5 | 96 | 12.1 ± 16.5 |
FSH peak, IU/L | 63 | 11 ± 5.1 | 33 | 9.8 ± 3.4 | 96 | 10.6 ± 4.6 |
LH/FSH peak ratio | 63 | 1 ± 1.1 | 33 | 1.2 ± 1 | 96 | 1.07 ± 1.1 |
Estradiol, pg/mL | 64 | 11.5 ± 18 | 39 | 12.3 ± 12.3 | 96 | 11.8 ± 16 |
GnRH analog treatment | 68 | 16 | 46 | 6 | 114 | 22 (19,3 %) |