Table 1 Characteristics of the included study reports
Insulin analog type | Insulin analog | Clinical trial ID | EMA report | First author of full-text article | Year | Design | Sample size | Mean age of total | Population | DM type | Mean duration of DM in years | Male (%) | Mean HbA1c (%) at baseline |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Rapid-acting | Insulin aspart (Novo Rapid) | NCT01388361 | N | Mathieu [29] | 2014 | RCT | 413 | 61.3 | A | II | 11.8 | 64 | 7.3 |
NCT00097071 | N | Weinzimer [30] | 2008 | RCT | 299 | 13.1 | C | I | 6.1 | 48 | 8.1 | ||
NCT00604656 | N | None | 2004 | RCT | 241 | 40.2 | A | I | 13.6 | 66 | 7.8 | ||
NCT00071448 | N | None | 2006 | RCT | 378 | 11.6 | C | I | 4.6 | 52 | 8.3 | ||
NCT01486940 | N | Hermansen [27] | 2004 | RCT | 644 | 39.1 | A | I | 15.2 | 63 | 8.4 | ||
NCT00065130 | N | Pettitt [31] | 2007 | RCT | 27 | 30.7 | A | GDM | – | 0 | 5.2 | ||
NCT00832182 | N | None [32]* | 2002 | Cohort | 75 | – | A | I | – | – | – | ||
NCT01707134 | N | Home [33] | 2006 | RCT | 753 | 38.8 | A | I | 15.2 | 58 | – | ||
Insulin glulisine (Apidra) | NCT00467376 | N | None | 2009 | RCT | 484 | – | A | I, II | 10.3 | – | 8.6 | |
NCT00115570 | N | None | 2009 | RCT | 572 | 12.5 | C | I | – | – | – | ||
NCT00290979 | N | None | 2006 | RCT | 267 | – | A | I | – | – | – | ||
NCT00290927 | N | None | 2005 | RCT | 393 | – | A | II | – | – | – | ||
NCT00135057 | Y | Bergenstal [34] | 2008 | RCT | 270 | 55.1 | A | II | 13.0 | 44 | 8.2 | ||
NCT00135096 | N | Ratner [35] | 2011 | RCT | 716 | 53.8 | A | II | 14.0 | 44 | 8.4 | ||
NCT00174668 | N | None | 2008 | RCT | 310 | – | A | II | – | – | – | ||
NCT00546702 | N | None | 2005 | CS | 140 | – | A | I | – | – | – | ||
NCT00545337 | N | None | 2007 | CS | 60 | 34.7 | A | I | 12.7 | 45 | – | ||
NCT00174642 | N | None | 2009 | RCT | 464 | 58.5 | A | II | – | 45 | 9.1 | ||
NCT00272012 | N | None | 2007 | RCT | 393 | – | A | II | – | – | – | ||
NCT00135941 | N | Testa [36] | 2012 | RCT | 388 | 54.0 | A | I, II | 16.1 | 47 | 7.8 | ||
NCT00135083 | N | Davidson [37] | 2011 | RCT | 343 | – | A | II | – | 5 | – | ||
NCT00272064 | N | Del Prato [38] | 2012 | RCT | 241 | 58.3 | A | II | 10.9 | 52 | 8.9 | ||
NCT00271284 | N | Renard [39] | 2011 | RCT | 135 | 46.8 | A | I | 18 | 61 | 7.1 | ||
NCT00397553 | N | None | 2009 | CS | 104 | 35.0 | A | I | 25.3 | – | 8.8 | ||
Insulin lispro (Humalog) | F3Z-MC-IOAE | Y | None | 1994 | RCT | 98 | 24.4 | M | I | 0.2 | 61 | – | |
F3Z-MC-IOAF | Y | None | 1994 | RCT | 377 | 56.1 | A | II | 7.8 | 56 | – | ||
F3Z-MC-IOAG | Y | None | 1993 | RCT | 1037 | 33.4 | M | I | 12.1 | 58 | 8.5 | ||
F3Z-MC-IOAH | Y | None | 1993 | RCT | 777 | 58.6 | A | II | 12.6 | 54 | 8.9 | ||
Pre-mixed | Biphasic insulin aspart (Novo Mix) | NCT00476437 | N | None | 2008 | RCT | 81 | 62.3 | A | II | 18.3 | 54 | 7.8 |
NCT00318786 | N | Kadowaki [40] | 2010 | RCT | 289 | 62.5 | A | II | 15.7 | 59 | 8.5 | ||
NCT00313001 | N | None | 2007 | RCT | 372 | 52.6 | A | II | – | 48 | 10.2 | ||
NCT00184574 | N | Cucinotta [41] | 2009 | RCT | 603 | 60.5 | A | II | – | 44 | 8.9 | ||
NCT00097877 | N | Bergenstal [42] | 2009 | RCT | 372 | 52.6 | A | II | – | 48 | 10.2 | ||
NCT00184600 | N | Holman [18] | 2009 | RCT | 708 | 61.7 | A | II | 9 | 64 | 8.5 | ||
NCT00097279 | Y | Raskin [43] | 2007 | RCT | 230 | 53.8 | A | II | 8.8 | 42 | 8.1 | ||
NCT00564668 | N | None | 2005 | RCT | 126 | 62.2 | A | II | 16.4 | 62 | 7.2 | ||
NCT00612599 | N | Parkner [44] | 2010 | RCT | 75 | 60.4 | A | II | 11.7 | 70 | 7.5 | ||
NCT00617565 | Y | None | 2004 | RCT | 219 | 55.8 | A | I, II | 11.1 | 56 | 8.8 | ||
NCT01467375 | N | None [45]* | 2005 | CS | 89 | 65.1 | A | II | 15.2 | 65 | 8.1 | ||
NCT01467323 | Y | Boehm [46] | 2002 | RCT | 294 | 54.0 | A | I, II | 15.3 | 58 | 8.3 | ||
Insulin lispro mix (Humalog Mix) | NCT00191581 | N | Gao [47] | 2008 | RCT | 120 | 55.7 | A | I, II | 11.4 | 40 | 8.1 | |
NCT00551356 | N | None | 2003 | RCT | 53 | 50.4 | A | II | 6.5 | 57 | – | ||
F3Z-JE-IOMO | N | None | 2003 | RCT | 215 | 55.9 | A | I, II | 15.0 | 58 | – | ||
F3Z-MC-IONA | N | None | 2006 | RCT | 106 | 52.4 | A | I, II | 10.4 | 52 | – | ||
NCT00036504 | N | None | 2007 | RCT | 105 | 54.9 | A | II | 8.9 | 62 | 8.6 |