Pretransplant visit

569
    
University of Alberta Hospital

Transplantation (including initial medication, based on 4 day stay: 1 preop and 3 postop)

91,414
 
15.0 %

LogNormal

μ = 11.412029

University of Alberta Hospital

σ = 0.149166

Total costs per transplantation (including all costs in the 23 days after a transplantation)

94,765
  
(via input)
  
Medication and followup (from day 4 postop onward)

Tacrolimus (per month)

450
 
7.5 %

LogNormal

μ = 6.106443

University of Alberta Hospital

σ = 0.074895

Mycophenolate mofetil (MMF; per month)

500
 
7.5 %

LogNormal

μ = 6.211803

University of Alberta Hospital

σ = 0.074895

Alemtuzumab (once per transplant)^{b}

0
    
University of Alberta Hospital

Basiliximab (once at 2nd transplant for about half of patients instead of Alemtuzumab)

3000
    
University of Alberta Hospital

Valganciclovir (for 14 weeks)

5000

375

7.5 %

LogNormal

μ = 8.514389

University of Alberta Hospital

σ = 0.074895

Anakinra (total for remaining 3 days after discharge)

574

43

7.5 %

LogNormal

μ = 6.349825

University of Alberta Hospital

σ = 0.074895

Immunosuppression (per cycle, drugs: see above)

713

53

7.5 %

LogNormal

μ = 6.56667

Calculated via data from University of Alberta Hospital

σ = 0.074895

Generic immunosuppression (per cycle)

238

18

7.5 %

LogNormal

μ =5.46808

Calculated as 1/3 of cost above (price reduction for generic version based on market prices)

σ = 0.074895

Costs for insulin therapy in graft survival state (per cycle)

64
  
(via input)
 
Calculated via data from [33] and based on [10] as 40 % of costs with intensive insulin therapy

Posttransplant checkup visit (at week 1, 2, at 6 months and 1 year and then once a year)

556

42

7.5 %

LogNormal

μ = 6.31800

University of Alberta Hospital

σ = 0.074895

Total per cycle (per year) costs for immunosuppression, followup and insulin (if applicable)

Full graft function for the first 6 months

1886 (30,175)
  
(via inputs)
 
Calculated via data from University of Alberta Hospital

Full graft function after the first 6 months

747 (11,956)
  
(via inputs)
 
Calculated via data from University of Alberta Hospital

Partial graft function for the first 6 months

1950 (31,196)
  
(via inputs)
 
Calculated via University of Alberta Hospital data and [33]

Partial graft function after the first 6 months

811 (12,977)
  
(via inputs)
 
Calculated via University of Alberta Hospital data and [33]

Intensive insulin therapy

Average healthcare costs of treating people with newly diagnosed diabetes (first 10 years) per cycle (per year)

Without complications for type 1 and 2 diabetes

159 (2552)

12

7.5 %

LogNormal

μ = 5.06920

Corrected data from [33]

σ = 0.074895

With complications for type 1 and 2 diabetes

602 (9632)

120

20.0 %

Gamma

α = 25.00000

Calculated from corrected data in [33]

β = 24.0796

Other costs (per occurrence)

Average extra costs of initial immunosuppressive or other complications

600

180

30.0 %

Gamma

α = 11.1111

Assumption based on [2] and expert opinion

β = 54.0000

Average extra costs of major immunosuppressive complications

6500

1300

20.0 %

Gamma

α = 25.0000

Assumption based on [2] and expert opinion

β = 260.0000
