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Table 1 Baseline characteristics of postmenopausal women with T2DM

From: Plasminogen activator inhibitor-1 concentrations and bone mineral density in postmenopausal women with type 2 diabetes mellitus

 

Osteoporosis n = 21

Osteopenia n = 47

Normal BMD n = 49

p

Age (year)

65,3 ± 10,2

67,4 ± 8,04

64,9 ± 8,7

NS

Waist (cm)

89,8 ± 11,2

96,0 ± 8,2

98,3 ± 12,0

c 0,03; b 0,003

BMI (kg/m2)

27,5 ± 5,6

29,1 ± 3,9

31,3 ± 5,1

a 0,02; b 0,002

Menopause duration (year)

17,8 ± 9,2

18,3 ± 8,5

14,7 ± 7,9

a 0,049

Diabetes duration (year)

9,1 ± 6,3

12,2 ± 7,1

12,1 ± 7,3

NS

HbA1c (%)

10,2 ± 2,24

10,1 ± 1,59

9,95 ± 1,9

NS

Cholesterol (mmol/l)

5,45 ± 1,62

5,13 ± 1,25

4,97 ± 1,41

NS

HDL cholesterol (mmol/l)

1,29 ± 0,25

1,22 ± 0,25

1,19 ± 0,27

NS

LDL cholesterol (mmol/l)

3,39 ± 1,02

3,03 ± 1,02

2,76 ± 1,12

ab 0,042

Triglicerydes (mmol/l)

1,98 ± 1,32

1,96 ± 0,79

2,37 ± 1,43

NS

Osteocalcin (ng/ml)

10,22 ± 7,67

8,37 ± 3,84

6,32 ± 2,87

a 0,025; b 0,0013

Insulin (mIU/l)

8,94 ± 4,14

9,97 ± 4,82

10,62 ± 5,69

NS

Pyrilinks (nMPD/mMc)

7,8 ± 3,1

7,41 ± 2,9

5,5 ± 2,1

a 0,001; b 0,0015

Crosslaps (ng/ml)

0,54 ± 0,25

0,49 ± 0,29

0,35 ± 0,21

a 0,012; b 0,0092

PAI-1 (U/l)

3,3 ± 2,1

3,5 ± 2,1

4,4 ± 1,9

a 0,042; b0,052

Fibrinogen (g/L)

4,1 ± 1,0

4,3 ± 0,8

4,0 ± 0,8

NS

CRP (mg/L)

5,77 ± 11,6

3,89 ± 3,67

3,74 ± 4,25

NS

Lumbar BMD (g/cm2)

0,707 ± 0,07

0,856 ± 0,04

1,036 ± 0,09

ab c <0,05

Hip BMD (g/cm2)

0,746 ± 0,13

0,838 ± 0,109

0,985 ± 0,147

ac b <0,05

  1. Chi square test; BMD bone mineral density, BMI body mass index, HDL high density lipoprotein, LDL low density lipoprotein, PAI 1 plasminogen activator inhibitor 1. Bolded p values are significant.
  2. aosteoporosis group vs. normal BMD group; bosteopenia vs. normal BMD group; costeoporosis vs. osteopenia group