Table 5 Association of thyroid dysfunction with mild cognitive impairment and Alzheimer’s disease, compared to normal thyroid function

All hypothyroidism (n = 14)

Alzheimer’s Disease (n = 145)

Crude

1.01(0.29–3.46)

Multivariate-adjusted^a

1.33(0.39–4.79)

Mild cognitive impairment (n = 56)

Crude

0.64(0.11–3.62)

Multivariate-adjusted^a

0.72(0.12–4.28)

All subclinical hypothyroidism (n = 9)

Alzheimer’s Disease (n = 142)

Crude

1.26(0.24–6.66)

Multivariate-adjusted^a

1.29(0.24–6.70)

Mild cognitive impairment (n = 56)

Crude

1.28(0.17–9.37)

Multivariate-adjusted^a

1.06(0.14–8.00)

All subclinical hyperthyroidism (n = 12)

Alzheimer Disease (n = 141)

Crude

1.01(0.18–5.64)

Multivariate-adjusted^a

1.08(0.19–6.13)

Mild cognitive impairment (n = 60)

Crude

0.26(0.05–1.34)

Multivariate-adjusted^a

0.25(0.05–1.30)