Table 1 Growth characteristics at adult height according to randomization group
From: Growth hormone (GH) dose-dependent IGF-I response relates to pubertal height gain
At Adult Height | 33 × 1 | 67 × 1 | 33 × 2 | 67 × 1 + 33 × 2 |
|---|---|---|---|---|
n = 38 | n = 30 | n = 36 | n = 66 | |
ITT all, n = 104 | Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD |
Age, years | 18.6 ± 1.5 | 18.6 ± 1.27 | 18.6 ± 1.79 | 18.6 ± 1.56 |
Adult heightSDS | −1.2 ± 0.68 | −0.9 ± 0.93 | −0.8 ± 0.88 | −0.8 ± 0.89 |
diffH-MPHSDS | 0.2 ± 0.80 | 0.3 ± 1.13 | 0.2 ± 1.00 | 0.2 ± 1.05 |
Total gain in heightSDS | 1.6 ± 0.83 | 2.1 ± 1.14* | 1.9 ± 0.82 | 2.0 ± 0.97* |
Prepubertal gain in heightSDS | 1.2 ± 0.85 | 1.4 ± 1.28 | 1.2 ± 0.71 | 1.3 ± 1.00 |
Pubertal gain in heightSDS | 0.4 ± 0.58 | 0.7 ± 0.90 | 0.7 ± 0.77 | 0.7 ± 0.83* |
Years from puberty | 5.7 ± 1.22 | 5.5 ± 1.51 | 5.9 ± 1.58 | 5.7 ± 1.55 |
Years from GH start | 8.5 ± 2.87 | 8.7 ± 3.21 | 8.9 ± 2.92 | 8.8 ± 3.03 |
Years on GH | 7.6 ± 2.88 | 7.7 ± 2.99 | 7.7 ± 3.04 | 7.7 ± 2.99 |
Years in study | 5.1 ± 1.24 | 4.9 ± 1.48 | 5.1 ± 1.54 | 5.0 ± 1.50 |
PP, boys, n = 82 | n = 34 | n = 23 | n = 25 | n = 48 |
Age, years | 18.7 ± 1.42 | 18.8 ± 1.14 | 18.8 ± 1.89 | 18.8 ± 1.56 |
Adult heightSDS | −1.2 ± 0.60 | −0.8 ± 0.84 | −0.8 ± 0.93 | −0.8 ± 0.88 |
diffH-MPHSDS | 0.2 ± 0.82 | 0.4 ± 1.05 | 0.2 ± 1.00 | 0.3 ± 1.02 |
Total gain in heightSDS | 1.5 ± 0.69 | 2.0 ± 0.88* | 1.9 ± 0.75a | 1.9 ± 0.81** |
Prepubertal gain in heightSDS | 1.00 ± 0.61 | 1.1 ± 0.58 | 1.2 ± 0.74 | 1.1 ± 0.67 |
Pubertal gain in heightSDS | 0.4 ± 0.60 | 0.9 ± 0.88* | 0.7 ± 0.75 | 0.8 ± 0.81* |
Years from puberty | 5.7 ± 1.18 | 5.6 ± 1.55 | 6.2 ± 1.81 | 5.9 ± 1.7 |
Years from GH start | 8.3 ± 2.62 | 8.5 ± 2.98 | 9.1 ± 3.25 | 8.8 ± 3.11 |
Years on GH | 7.5 ± 2.62 | 7.5 ± 2.78 | 8.0 ± 3.16 | 7.8 ± 2.96 |
Years in study | 5.1 ± 1.16 | 4.9 ± 1.45 | 5.4 ± 1.73 | 5.1 ± 1.6 |
ITT, Girls, n = 14 | n = 3 | n = 5 | n = 6 | n = 11 |
Age, years | 16.7 ± 1.46 | 17.2 ± 1.14 | 17.3 ± 1.31 | 17.2 ± 1.18 |
Adult heightSDS | 0.0 ± 0.49 | −0.6 ± 0.94 | −1.3 ± 0.71* | −1.0 ± 0.87 |
diffH-MPHSDS | 0.2 ± 0.50 | 0.3 ± 0.95 | −0.2 ± 0.96 | 0.0 ± 0.94 |
Total gain in heightSDS | 3.0±0.98 | 3.1±1.80 | 1.6±0.97 | 2.2±1.54 |
Prepubertal gain in heightSDS | 2.9±1.50 | 3.1±2.29 | 1.1±0.51 | 2.0±1.83 |
Pubertal gain in heightSDS | 0.3±0.33 | −0.1±0.71 | 0.4±0.89 | 0.2±0.82 |
Years from puberty | 4.5±0.54 | 5.8±1.55 | 5.6±0.91 | 5.7±1.18 |
Years from GH start | 10.8±5.46 | 10.9±3.90 | 8.1±1.72 | 9.4±3.12 |
Years on GH | 10.1±4.92 | 9.4±3.95 | 7.1±1.50 | 8.1±2.97 |
Years in study | 4.1±1.24 | 5.5±1.58 | 4.6±1.09 | 5.0±1.34 |