Table 2 Characteristics of patients at 1-year follow-up with rGH Therapy
Variable | Total n = 44 | GHD n = 18 | ISS n = 10 | SGA n = 9 | TS and variants n = 4 | Others n = 3 | P value |
|---|---|---|---|---|---|---|---|
Female, n (%) | 21 (47.7 %) | 7 (39.0 %) | 5 (50.0 %) | 4 (44.4 %) | 4 (100.0 %) | 1 (33.3 %) | 0.279* |
Age in years, median (IQR) | 9.7 (7.2, 11.6) | 7.3 (6.6, 11.6) | 11.6 (9.7, 12.1) | 8.9 (8.1, 10.7) | 10.7 (8.6, 11.4) | 7.7 (3.7, 14.7) | 0.230 |
Pre-pubertal, n/N (%) | 30/37 (81.1 %) | 14/16 (87.5 %) | 6/9 (66.7 %) | 6/7 (85.7 %) | 2/3 (66.7 %) | 2/2 (100.0 %) | 0.641 |
Height SDS, mean (SD) | −2.14 (0.59) | −2.11 (0.57) | −2.49 (0.55) | −1.82 (0.59) | −2.28 (0.73) | −1.98 (0.21) | 0.158 |
Height SDS change, median (IQR) | 0.54 (0.29, 0.75) | 0.57 (0.33, 0.83) | 0.17 (0.16, .41) | 0.74 (0.59, 0.76) | 0.40 (0.22, 0.61) | 0.77 (0.44, 0.93) | 0.005 |
BMI SDS, median (IQR) | −0.73 (−1.57, −0.21) | −0.73 (−1.34, −0.36) | −0.51 (−1.22, −0.09) | −1.59 (−2.00, −1.05) | −0.31 (−1.61, 1.02) | −0.19 (−0.59, 0.35) | 0.136 |
BMI change, median (IQR) | −0.04 (−0.49, 0.24) | −0.23 (−0.49, 0.07) | 0.19 (−0.34, 0.59) | 0.17 (−0.59, 0.48) | −0.32 (−1.01, 0.43) | −0.36 (−0.43, 1.06) | 0.431 |
Significant responders, n (%) | 33 (75.0 %) | 15 (83.3 %) | 4 (40.0 %) | 9 (100.0 %) | 2 (50.0 %) | 3 (100.0 %) | 0.012 |