Table 3 Predictors of switch to BOT: Univariate and multivariate (pooled) HRs and corresponding lower and upper bounds of the 95 % CIs

Univariate

 Age

1.000 (0.998,1.002)

1.002 (1.001,1.004)

 BMI

1.016 (1.012,1.020)

1.006 (1.004,1.010)

 Diabetes duration

1.044 (1.041,1.047)

1.003 (0.999,1.007)

 HbA1c

1.264 (1.245,1.284)

1.003 (0.984,1.022)

 FPG

1.127 (1.109,1.046)

1.011 (0.999,1.023)

 Gender

0.934 (0.891,0.981)

1.001 (0.963,1.040)

 Microvascular diseases^a

1.226 (1.168,1.287)

0.974 (0.936,1.014)

 Macrovascular diseases^a

1.115 (1.056,1.178)

1.131 (1.083,1.182)

 Hypoglycaemia^a

2.567 (1.850,3.563)

1.007 (0.634,1.599)

 No. OADs at baseline 2 vs. 1

1.288 (1.206,1.376)

0.679 (0.636,0.725)

 No. OADs at baseline 3 vs. 1

1.295 (1.054,1.592)

0.605 (0.483,0.758)

 Concomitant Medication yes vs. no

1.144 (1.090,1.200)

0.834 (0.802,0.866)

Multivariate

 Age

0.993 (0.991,0.996)

1.003 (1.001,1.005)

 BMI

1.012 (1.007,1.017)

1.009 (1.005,1.012)

 Diabetes duration

1.046 (1.043,1.049)

1.003 (0.999,1.007)

 HbA1c

1.227 (1.197,1.257)

0.999 (0.970,1.029)

 FPG

1.022 (0.999,1.046)

1.014 (0.997,1.033)

 Gender

0.950 (0.903,0.998)

0.995 (0.956,1.035)

 Microvascular diseases^a

1.141 (1.082,1.203)

0.947 (0.908,0.988)

 Macrovascular diseases^a

1.065 (1.004,1.130)

1.152 (1.100,1.208)

 Hypoglycaemia^a

1.708 (1.208,2.415)

0.956 (0.601,1.520)

 No. OADs at baseline 2 vs. 1

1.121 (1.047,1.199)

0.680 (0.636,0.727)

 No. OADs at baseline 3 vs. 1

0.981 (0.796,1.210)

0.604 (0.482,0.758)

 Concomitant Medication yes vs. no

1.094 (1.042,1.149)

0.824 (0.793,0.857)