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Table 1 High-resolution transthoracic echocardiography performed on conscious MuRF3−/− and age-matched wild type mice at baseline, 6 weeks, 12 weeks, 15 weeks, 22 weeks, and 26 weeks high fat diet. Data represent means ± SEM. A One Way ANOVA was performed (¶p < 0.05), followed by Holm-Sidak Multiple Comparison vs. Control Group (MuRF3+/+ 26 Weeks High Fat Diet)

From: Muscle ring finger-3 protects against diabetic cardiomyopathy induced by a high fat diet

           

 
 

MuRF3

MuRF3

MuRF3

MuRF3

MuRF3

MuRF3

MuRF3

MuRF3

MuRF3

MuRF3

MuRF3

MuRF3

 

+/+

-/-

+/+

-/-

+/+

-/-

+/+

-/-

+/+

-/-

+/+

-/-

 

Baseline

Baseline

6 Wks High Fat Diet

6 Wks High Fat Diet

12 Wks High Fat Diet

12 Wks High Fat Diet

15 Weeks High Fat Diet

15 Weeks High Fat Diet

22 Wks High Fat Diet

22 Wks High Fat Diet

26 Weeks High Fat Diet

26 Weeks High Fat Diet

 

N=11

N=7

N=9

N=10

N=9

N=10

N=9

N=10

N=9

N=10

N=9

N=10

 

(1)

(2)

(3)

(4)

(5)

(6)

(7)

(8)

(9)

(10)

(11)

(12)

AWTD (mm)

1.03±0.02

1.07±0.03

1.14±0.04

0.98±0.04

1.03±0.04

1.01±0.03

1.04±0.04

1.02±0.04

1.09±0.04

1.09±0.02

1.08±0.03

1.06±0.04

AWTS (mm)

1.65±0.04

1.68±0.05

1.78±0.05

1.59±0.03

1.62±0.09

1.60±0.05

1.71±0.06

1.54±0.07

1.66±0.04

1.68±0.04

1.71±0.04

1.60±0.05

LVEDS (mm)¶

1.25±0.08*

1.33±0.03*

1.45±0.07*

1.70±0.12

1.70±0.12

1.73±0.12

1.75±0.12

2.05±0.12

1.86±0.10

1.85±0.13

1.95±0.06

2.08±0.14

PWTD (mm)

0.99±0.03

1.01±0.06

1.05±0.04

1.00±0.03

0.99±0.04

0.94±0.03

1.00±0.03

0.93±0.04

1.06±0.03

1.03±0.05

1.01±0.04

1.01±0.04

PWTS (mm)¶

1.65±0.07

1.64±0.06

1.63±0.05

1.43±0.07

1.52±0.09

1.37±0.07

1.51±0.09

1.31±0.04*

1.49±0.07

1.46±0.08

1.50±0.05

1.37±0.07

LV Vol;d (μl)

31.3±3.9

33.8±1.7

37.0±2.7

34.8±3.5

38.0±2.4

31.1±4.0

38.6±3.8

40.5±4.3

42.2±2.9

38.6±4.8

49.0±4.1

45.1±6.1

LV Vol;s (μl)¶

4.1±0.7*

4.5±0.3*

5.8±0.7*

8.8±1.3

9.0±1.5

9.5±1.8

9.8±1.7

14.2±2.0

11.0±1.4

11.3±2.2

12.0±0.9

15.1±2.6

LV Mass/BW (mg/g)

4.33±0.21*

5.42±0.29*

4.11±0.21*

3.89±0.11*

3.16±0.15

3.16±0.25

3.04±0.16

3.40±0.10

3.18±0.10

3.65±0.16

3.35±0.21

3.78±0.17

HR (bpm)

629±15

619±23

676±6

664±13

681±8

674±9

694±8

697±13

656±19

665±7

662±15

659±9

  1. HR, heart rate; ExLVD, external left ventricular diameter; bpm, heart beats per minute; AWTD, anterior wall thickness in cxxdiastole; AWTS, anterior wall thickness in systole; PWTD, posterior wall thickness in diastole; PWTS, posterior wall thickness in systole; LVEDD, left ventricular end-diastolic dimension; LVESD, left ventricular end-systolic dimension; FS, fractional shortening, calculated as (LVEDD-LVESD)/LVEDD x 100; EF%, ejection fraction calculated as (end Simpson’s diastolic volume – end Simpson’s systolic volume)/end Simpson’s diastolic volume * 100
  2. *p < 0.05 vs. MuRF3+/+ 26 Wks High Fat Diet ()