From: Muscle ring finger-3 protects against diabetic cardiomyopathy induced by a high fat diet
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 | MuRF3 | MuRF3 | MuRF3 | MuRF3 | MuRF3 | MuRF3 | MuRF3 | MuRF3 | MuRF3 | MuRF3 | MuRF3 | MuRF3 |
 | +/+ | -/- | +/+ | -/- | +/+ | -/- | +/+ | -/- | +/+ | -/- | +/+ | -/- |
 | Baseline | Baseline | 6 Wks High Fat Diet | 6 Wks High Fat Diet | 12 Wks High Fat Diet | 12 Wks High Fat Diet | 15 Weeks High Fat Diet | 15 Weeks High Fat Diet | 22 Wks High Fat Diet | 22 Wks High Fat Diet | 26 Weeks High Fat Diet | 26 Weeks High Fat Diet |
 | N=11 | N=7 | N=9 | N=10 | N=9 | N=10 | N=9 | N=10 | N=9 | N=10 | N=9 | N=10 |
 | (1) | (2) | (3) | (4) | (5) | (6) | (7) | (8) | (9) | (10) | (11) | (12) |
AWTD (mm) | 1.03±0.02 | 1.07±0.03 | 1.14±0.04 | 0.98±0.04 | 1.03±0.04 | 1.01±0.03 | 1.04±0.04 | 1.02±0.04 | 1.09±0.04 | 1.09±0.02 | 1.08±0.03 | 1.06±0.04 |
AWTS (mm) | 1.65±0.04 | 1.68±0.05 | 1.78±0.05 | 1.59±0.03 | 1.62±0.09 | 1.60±0.05 | 1.71±0.06 | 1.54±0.07 | 1.66±0.04 | 1.68±0.04 | 1.71±0.04 | 1.60±0.05 |
LVEDS (mm)¶ | 1.25±0.08* | 1.33±0.03* | 1.45±0.07* | 1.70±0.12 | 1.70±0.12 | 1.73±0.12 | 1.75±0.12 | 2.05±0.12 | 1.86±0.10 | 1.85±0.13 | 1.95±0.06 | 2.08±0.14 |
PWTD (mm) | 0.99±0.03 | 1.01±0.06 | 1.05±0.04 | 1.00±0.03 | 0.99±0.04 | 0.94±0.03 | 1.00±0.03 | 0.93±0.04 | 1.06±0.03 | 1.03±0.05 | 1.01±0.04 | 1.01±0.04 |
PWTS (mm)¶ | 1.65±0.07 | 1.64±0.06 | 1.63±0.05 | 1.43±0.07 | 1.52±0.09 | 1.37±0.07 | 1.51±0.09 | 1.31±0.04* | 1.49±0.07 | 1.46±0.08 | 1.50±0.05 | 1.37±0.07 |
LV Vol;d (μl) | 31.3±3.9 | 33.8±1.7 | 37.0±2.7 | 34.8±3.5 | 38.0±2.4 | 31.1±4.0 | 38.6±3.8 | 40.5±4.3 | 42.2±2.9 | 38.6±4.8 | 49.0±4.1 | 45.1±6.1 |
LV Vol;s (μl)¶ | 4.1±0.7* | 4.5±0.3* | 5.8±0.7* | 8.8±1.3 | 9.0±1.5 | 9.5±1.8 | 9.8±1.7 | 14.2±2.0 | 11.0±1.4 | 11.3±2.2 | 12.0±0.9 | 15.1±2.6 |
LV Mass/BW (mg/g) | 4.33±0.21* | 5.42±0.29* | 4.11±0.21* | 3.89±0.11* | 3.16±0.15 | 3.16±0.25 | 3.04±0.16 | 3.40±0.10 | 3.18±0.10 | 3.65±0.16 | 3.35±0.21 | 3.78±0.17 |
HR (bpm) | 629±15 | 619±23 | 676±6 | 664±13 | 681±8 | 674±9 | 694±8 | 697±13 | 656±19 | 665±7 | 662±15 | 659±9 |