Fig. 2
From: Muscle ring finger-3 protects against diabetic cardiomyopathy induced by a high fat diet
MuRF3−/− experience significant deficits in cardiac function after challenge with high fat diet. a qPCR analysis of heart failure associated fetal gene expression in MuRF3−/− mice at baseline and after 26 weeks high fat diet challenge. b Fasting blood glucose and fasting serum insulin levels. c Histological analysis of MuRF3−/− and wildtype hearts post-high fat diet challenge. d/e MuRF3−/− mice exhibit an accelerated heart failure by 6 weeks after the initiation of the high fat diet. Values expressed as Mean ± SE. N indicated in bars (a & b) or below graph (e). The significance of observed differences in grouped mean values was determined using a One Way ANOVA followed by Holm-Sidak pairwise post hoc analysis. *p < 0.001, #p < 0.05