Figure 2
U50,488H improved vasoconstrictive and vasodilative functions of thoracic aortas in DM rats. Concentration-response curves for KCl (0–100 mmol/L) (A) or NE (10−9-10−4 mol/L) (B) induced vasoconstriction. U50,488H administration induced a rightward shift in the concentration-response curves, while nor-BNI administration induced a leftward shift in the concentration-response curves. (C) Concentration-response curves for ACh-induced vasodilation showed that U50,488H treatment improved vasodilative function of thoracic aortas. (D) Concentration-response curves for SNP-induced vasodilation showed no statistical differences among all five groups. *P < 0.05 vs. CON group, #P < 0.05 vs. DM group. (n = 5).