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Table 2 Effect of rosiglitazone treatment on expression levels (ΔCt) of PPARγ, PPARγ responsive genes and NFκB related genes in type 2 diabetic patients1,2

From: Anti-inflammatory effect of rosiglitazone is not reflected in expression of NFκB-related genes in peripheral blood mononuclear cells of patients with type 2 diabetes mellitus

Gene

ΔΔCt (after – before treatment)

p-value3

PPARγ

0.31 (-0.70 – 1.29)

0.213

CD36

0.37 (-0.93 – 0.90)

0.248

LPL

-0.39 (-0.90 – 1.26)

0.248

INFγ

-0.53 (-3.04 – 0.62)

0.045

IL1R1

0.37 (-1.16 – 1.51)

0.041

RELB

0.31 (-0.23 – 2.27)

0.016

SLC20A1

0.41 (-1.03 – 1.93)

0.033

  1. 1 The expression of 84 genes related to NFκB was profiles using the RT2Profiler™ PCR Array; n = 11
  2. 2 Values are reported as ΔΔCt values and presented as medians with ranges. A negative ΔΔCt value corresponds with an upregulation and a positive ΔΔCt value with a downregulation of the gene after rosiglitazone treatment.
  3. 3 Gene expression levels (ΔCt values) were analysed with the non-parametric Wilcoxon signed rank test. Differences were considered significant at a p-value < 0.05
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BMC Endocrine Disorders

ISSN: 1472-6823

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