Diabetes-induced renal dysfunction. Effect of STZ-induced diabetes (5-week post-STZ) on, A) Creatinine clearance, and B) Urinary albumin excretion in male Sprague-Dawley rats. Values are expressed as Mean ± SEM (n = 6). * P < 0.05 compared with age-matched (5-week) controls. C) Periodic acid-Schiff (PAS) stained sections of control and (5-week post-STZ) diabetic rat kidneys observed under 400× magnification. Arrows indicate regions of renal damage. Experiments were repeated three times with similar results.