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Table 2 Dose effect of glucagon-like peptide 1. Effects of graded doses of GLP-1 and usual insulin before breakfast in volunteers with type 1 diabetes with no endogenous insulin secretion, with number of subjects studied at each dose. Time-averaged incremental (delta) responses (area under the curve divided by total time) of plasma glucose through 3 hours, pancreatic polypeptide(HPP), 0 to 30 min, and glucagon, 0 to 60 min, mean ± se. Polynomial regression analysis (R2) for dose vs incremental responses.

From: Glucagon-like peptide 1 improved glycemic control in type 1 diabetes

Dose μg/kg n Glucose mmol/l HPP pmol/l Glucagon ng/l
0 15 6.5 ± 0.8 27.4 ± 4.6 11.9 ± 3.7
0.32 9 5.8 ± 1.7 14.1 ± 6.4 8.5 ± 4.5
0.63 12 5.2 ± 0.8 3.1 ± 2.2 6.6 ± 2.5
1.25 11 4.7 ± 0.8 1.7 ± 0.89 5.1 ± 6.7
R2   0.99 0.99