Figure 7

Representative examples of CgA expression in PNETs and their paired tissues. Left panel: HE staining; middle panel: CgA IHC, 10×; right panel: CgA IHC, 20×. Figure 7 A shown HE staining of a gastrinoma located in duodenum, Figure 7 B shown the strong expression of CgA protein in gastrinoma tissue and Figure 7 C shown scattered CgA positive cells in non-tumoral duodenum tissue. Figure 7 D, Figure 7 G and Figure 7 J shown HE staining of 3 different insulinomas, respectively. Figure 7 E-F, Figure 7 H-I and Figure 7 K-L shown the very strong signals of CgA, strong signals of CgA and medium signals of CgA in 3 different insulinomas, respectively. In contrast, no expression of CgA can be seen in the interstitial tissues within the tumor and in the pancreatic exocrine tissues.