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Table 4 Hazard ratios of severe hypoglycaemia events and chronic kidney disease (CKD) for the risk of cause-specific death in patients with type 2 diabetes

From: Hypoglycaemia, chronic kidney disease and death in type 2 diabetes: the Hong Kong diabetes registry

Causes of death

Number of death (%)

Hazard ratio

95% CI

P value

Cardiovascular disease

    

Model 1

    

Hypoglycemia events

14(3.61%)

1.48

0.86 to 2.54

0.1619

CKD

83(9.25%)

7.15

5.45 to 9.38

<0.0001

Model 2

    

Hypoglycemia events

 

0.99

0.57 to 1.71

0.9603

CKD

 

1.63

1.19 to 2.23

0.0021

Model 3

    

Hypoglycemia events

 

0.99

0.57 to 1.72

0.9790

CKD

 

1.54

1.20 to 2.13

0.0081

Renal disease

    

Model 1

    

Hypoglycemia events

26(6.70%)

4.27

2.76 to 6.61

<0.0001

CKD

88(9.81%)

20.92

14.79 to 29.58

<0.0001

Model 2

    

Hypoglycemia events

 

3.20

2.03 to 5.02

<0.0001

CKD

 

3.47

2.35 to 5.15

<0.0001

Model 3

    

Hypoglycemia events

 

3.10

1.97 to 4.89

<0.0001

CKD

 

3.42

2.29 to 5.11

<0.0001

Respiratory disease

    

Model 1

    

Hypoglycemia events

13(3.35%)

2.29

1.29 to 4.07

0.0048

CKD

45(5.02%)

5.19

3.65 to 7.39

<0.0001

Model 2

    

Hypoglycemia events

 

1.24

0.69 to 2.23

0.4741

CKD

 

1.54

1.03 to 2.31

0.0358

Model 3

    

Hypoglycemia events

 

1.21

0.67 to 2.18

0.5235

CKD

 

1.44

0.95 to 2.17

0.0845

All-site cancer

    

Model 1:

    

Hypoglycemia events

24(6.19%)

3.21

2.10 to 4.92

<0.0001

CKD

28(3.12%)

1.39

0.94 to 2.08

0.1030

Model 2

    

Hypoglycemia events

 

2.09

1.34 to 3.26

0.0011

CKD

 

1.00

0.64 to 1.54

0.9805

Model 3

    

Hypoglycemia events

 

1.97

1.26 to 3.07

0.0027

CKD

 

0.92

0.59 to 1.44

0.7192

  1. Adjustment schemes for models 1 to 3 were the same as listed in Tables 2 and 3.
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