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Table 1 Plasma steroid profile of the patient

From: The clinical significance of aldosterone synthase deficiency: report of a novel mutation in the CYP11B2 gene

 

Basal (nmol/L)

Post-ACTH stimulation (nmol/L)

  

Aldosterone

0.166 (0.39-2.44)

0.19 (0.01 – 0.55)

  

18-OH-Corticosterone (18-OHB)

7.06 (0.56 – 1.46)

12.1 (0.83 – 5.5)

  

Corticosterone

44.4 (0.14 – 14.23)

151.8 (34.0 - 208.4)

  

18-OH-deoxycorticosterone

1.64 (0.13-0.72)

5.28 (0.58 – 6.1)

  

Deoxycorticosterone

0.57 (0.09 – 0.57)

2.36 (0.27 – 1.35)

  

Progesterone

1.94 (0.095 – 3.15)

2.96 (0.52 – 2.55)

  

17-hydroxyprogesterone

3.09 (0.24 – 4.93)

15.2 (1.88 – 10.96)

  

11-Deoxycortisol

2.22 (0.15-2.58)

14.5 (1.36 - 9.44)

  

Cortisol

274.3 (59.9 - 480)

721.5 (317.3 – 979.3)

  

Cortisone

161.2 (6.37-123.6)

59.9 (34.8 – 79.7)

  

Ratio

    

  B/18-OHB

6

12

  

  18-OHB/ aldo

43

63

  
  1. Plasma steroid profile showed low aldosterone level, elevated 18-hydroxycorticosterone (18-OHB), low corticosterone/18-OHB and high 18-OHB/aldosterone ratios, compatible with type 2 aldosterone synthase deficiency.