Skip to main content

Table 1 Plasma steroid profile of the patient

From: The clinical significance of aldosterone synthase deficiency: report of a novel mutation in the CYP11B2 gene

  Basal (nmol/L) Post-ACTH stimulation (nmol/L)   
Aldosterone 0.166 (0.39-2.44) 0.19 (0.01 – 0.55)   
18-OH-Corticosterone (18-OHB) 7.06 (0.56 – 1.46) 12.1 (0.83 – 5.5)   
Corticosterone 44.4 (0.14 – 14.23) 151.8 (34.0 - 208.4)   
18-OH-deoxycorticosterone 1.64 (0.13-0.72) 5.28 (0.58 – 6.1)   
Deoxycorticosterone 0.57 (0.09 – 0.57) 2.36 (0.27 – 1.35)   
Progesterone 1.94 (0.095 – 3.15) 2.96 (0.52 – 2.55)   
17-hydroxyprogesterone 3.09 (0.24 – 4.93) 15.2 (1.88 – 10.96)   
11-Deoxycortisol 2.22 (0.15-2.58) 14.5 (1.36 - 9.44)   
Cortisol 274.3 (59.9 - 480) 721.5 (317.3 – 979.3)   
Cortisone 161.2 (6.37-123.6) 59.9 (34.8 – 79.7)   
Ratio     
  B/18-OHB 6 12   
  18-OHB/ aldo 43 63   
  1. Plasma steroid profile showed low aldosterone level, elevated 18-hydroxycorticosterone (18-OHB), low corticosterone/18-OHB and high 18-OHB/aldosterone ratios, compatible with type 2 aldosterone synthase deficiency.