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Table 1 Severity of hand-foot syndrome

From: Hand-foot syndrome associated with use of sorafenib in a patient with papillary thyroid cancer: a case report

Grade Hand-foot syndrome
1 Minimal skin changes or dermatitis (e.g., erythema, edema, or hyperkeratosis) without pain.
2 Skin changes (e.g., peeling, blisters, bleeding, edema, or hyperkeratosis) with pain; limiting instrumental activities of daily living.
3 Severe skin changes (e.g., peeling, blisters, bleeding, edema, or hyperkeratosis) with pain; limiting self care activities of daily living.