Table 1 Severity of hand-foot syndrome

1

Minimal skin changes or dermatitis (e.g., erythema, edema, or hyperkeratosis) without pain.

2

Skin changes (e.g., peeling, blisters, bleeding, edema, or hyperkeratosis) with pain; limiting instrumental activities of daily living.

3

Severe skin changes (e.g., peeling, blisters, bleeding, edema, or hyperkeratosis) with pain; limiting self care activities of daily living.