Skip to main content

Table 1 Body and heart mass

From: Partial deficiency of HIF-1α stimulates pathological cardiac changes in streptozotocin-induced diabetic mice

Genotype

Wt

Wt

Hif1a +/-

Hif1a +/-

Parameter

Non-diabetic

Diabetic

Non-diabetic

Diabetic

Males (n)

7

8

10

8

BM (g)

28.0 ± 0.4

24.8 ± 0.7*

28.4 ± 0.6

22.9 ± 0.8*

HM (mg)

106 ± 2

88 ± 3*

104 ± 4

86 ± 3*

RV/BM

0.77 ± 0.03

0.74 ± 0.04

0.76 ± 0.04

0.73 ± 0.02

LV/BM

2.18 ± 0.03

1.98 ± 0.06*

2.07 ± 0.04

1.96 ± 0.03*

Females (n)

7

12

10

8

BM (g)

22.0 ± 0.7

22.1 ± 0.6

22.1 ± 0.5

20.5 ± 0.4

HM (mg)

81 ± 1

80 ± 1

79 ± 2

77 ± 1

RV/BM

0.80 ± 0.04

0.80 ± 0.02

0.74 ± 0.02

0.73 ± 0.03

LV/BM

2.34 ± 0.07

2.31 ± 0.08

2.26 ± 0.05

2.34 ± 0.14

  1. Values are means ± SEM from indicated number of animals in each group. Abbreviations: BM, body mass; HM, heart mass; LV, left ventricular mass; RV, right ventricular mass. Statistical significance was assessed by 2-way ANOVA with Tukey’s multiple-comparison test, *P < 0.05 vs. non-diabetic Wt; P < 0.05 vs. non-diabetic Hif1a +/-.