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Table 2 Differences in characteristics according to diagnosis of type 2 diabetes and prediabetes based on the oral glucose tolerance test and the haemoglobin A1c level

From: Screening South Asians for type 2 diabetes and prediabetes: (1) comparing oral glucose tolerance and haemoglobin A1c test results and (2) comparing the two sets of metabolic profiles of individuals diagnosed with these two tests

Type 2 diabetes

Nondiabetic

HbA1c

OGTT only

p-value for HbA1c vs. OGTT only

 

(OGGT-/Hba1c-)n = 894

(HbA1c+)n = 31

(OGTT+/HbA1c-)n = 19

 

FPG in mmol/l a

4.9 (4.6–5.3)

6.7 (5.5–7.4)

5.7 (5.3–6.5)

<0.05

2 hour PG in mmol/l a

5.2 (4.4–6.3)

9.2 (5.9–12.8)

12.0 (11.4–12.4)

<0.05

HbA1c in %a

5.6 (5.3–5.8)

6.8 (6.6–7.1)

5.9 (5.6–6.3)

0.06

HbA1c in mmol/mol a

38 (34–40)

51 (49–54)

41 (38–45)

0.06

Age in years

43.4 (35.0–50.3)

46.0 (38.3–56.3)

48.7 (43.1–52.3)

0.43

Male

350 (39.1)

12 (38.7)

10 (52.6)

0.72

BMI in kg/m2

25.5 (23.0–28.2)

28.6 (25.4–29.9)

27.9 (24.8–30.0)

0.68

Waist circumference in cm

87.2 (80.3–95.0)

97.2 (90.0–102.3)

92.0 (88.3–100.0)

0.35

Systolic blood pressure in mmHg

124 (114–136)

134 (117–144)

125 (118–143)

0.67

Diastolic blood pressure in mmHg

80 (73–88)

86 (82–96)

82 (74–94)

0.20

Insulin in pmol/l

70.8 (47.9–100.7)

120.1 (75.0–190.0)

128.5 (90.6–195.0)

0.63

HOMA-s in %b

75.4 (53.5–108.7)

44.5 (28.2–67.9)

40.7 (27.2–59.0)

0.67

HOMA-b in %b

119.3 (93.2–152.0)

112.5 (70.9–138.5)

122.9 (91.5–180.3)

0.17

Prediabetes c

Non-pre-diabetic

HbA1c

OGTT only

p-value

 

(OGTT-/HbA1c-), n = 479

HbA1c +) n = 353

(OGTT+/HbA1c-) n = 62

 

FPG in mmol/l*a

4.8 (4.5–5.0)

5.2 (4.9–5.6)

5.6 (4.9–5.8)

<0.05

2 hour PG in mmol/l a

4.9 (4.2–5.8)

5.9 (4.8–7.2)

7.0 (5.4–8.2)

<0.05

HbA1c in %a

5.4 (5.2–5.5)

5.9 (5.7–6.0)

5.4 (5.2–5.6)

<0.05

HbA1c in mmol/mol a

35 (33–37)

41 (39–42)

36 (33–38)

<0.05

Age in years

40.1 (31.1–47.1)

48.1 (41.3–53.4)

46.0 (39.4–52.1)

0.19

Male in %

163 (34.0)

154 (43.6)

32 (51.6)

0.06

BMI in kg/m2

24.7 (22.2–27.3)

26.5 (24.1–29.6)

26.5 (23.4–29.3)

0.74

Waist circumference in cm

83.7 (77.2–91.0)

90.5 (84.9–99.1)

92.2 (84.7–99.6)

0.66

Systolic blood pressure in mmHg

120 (110–131)

128 (118–142)

129 (117–137)

0.61

Diastolic blood pressure in mmHg

77 (71–84)

82 (76–90)

81 (75–88)

0.26

Insulin in pmol/l

67.4 (45.1–95.1)

79.1 (54.2–116)

79.9 (62.5–116.5)

0.54

HOMA-s in %b

79.2 (57.9–117.5)

67.2 (46.7–98.4)

65.6 (45.4–83.1)

0.47

HOMA-b in %b

122.3 (96.2–156.0)

113 (81.1–151.2)

112.7 (85.5–138.3)

0.43

  1. Data are presented as medians (interquartile range) or n (percentages).
  2. aVariables on which the classification of prediabetes and type 2 diabetes was based.
  3. bHOMA-s and HOMA-b were determined from FPG and insulin levels (pmol/l) with the HOMA Calculator (University of Oxford)[16].
  4. cAll participants with type 2 diabetes according to either HbA1c or OGTT were excluded from the analyses for prediabetes.
  5. BMI, body mass index; FPG, fasting plasma glucose; HbA1c, glycated haemoglobin A1c; OGTT, oral glucose tolerance test; PG, plasma glucose.
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BMC Endocrine Disorders

ISSN: 1472-6823

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