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Table 1 Summary of the included studies in the meta-analysis

From: Sodium glucose co-transport 2 inhibitors in the treatment of type 2 diabetes mellitus: a meta-analysis of randomized double-blind controlled trials

Author Year Duration (wk) Drug before Background regimen Group 1 (n) Group 2 (n) Group 3 (n) Group 4 (n) Group 5 (n) Group 6 (n)
Rosenstock J et al S1 [28] 2012 12 Metformin Metformin PBO (65) CANA 50 mg QD (64) CANA 100 mg QD (64) CANA 200 mg QD (65) CANA 300 mg QD (64) CANA 300 mg BID (64)
Yale JF et al [29] 2013 26 N/R N/R PBO (90) CANA 100 mg QD (90) CANA 300 mg QD (89)    
Stenlof K et al [16] 2013 26 Diet and exercise - PBO (192) CANA 100 mg QD (195) CANA 300 mg QD (197)    
Ferrannini E et al S1 [32] 2013 12    PBO (82) EMPA 5 mg QD (81) EMPA 10 mg QD (81) EMPA 25 mg QD (82)   
Fonseca VA et al [31] 2012 12 N/R - PBO (69) IPRA 12.5 mg QD (70) IPRA 50 mg QD (67) IPRA150 mg QD (68) IPRA 300 mg QD (68)  
Wilding JPH et al S1 [30] 2013 12 Metformin - PBO (66) IPRA 12.5 mg QD (69) IPRA 50 mg QD (68) IPRA 150 mg QD (67) IPRA 300 mg QD (72)  
Wilding JPH et al S2 [18] 2009 12   Insulin PBO (19) DAPA 10 mg QD (23) DAPA 20 mg QD (23)    
Bailey CJ et al S1 [19] 2012 24 Naïve - PBO (68) DAPA 1 mg QD (72) DAPA 2.5 mg QD (72) DAPA 5.0 mg QD (66)   
Ferrannini E et al S2 [20] 2010 24 Naïve - PBO (75) DAPA 2.5 mg QD (65) DAPA 5.0 mg QD (64) DAPA 10 mg QD (70)   
Henry RR et al [21] 2012 24 Naïve Metformin PBO 1 (201) DAPA 5 mg QD (194) DAPA 10 mg QD (211) PBO 2 (208)   
Strojek K et al [22] 2011 24 Glimepiride Glimepiride PBO (145) DAPA 2.5 mg QD (154) DAPA 5 mg QD (142) DAPA 10 mg QD (151)   
Bailey CJ et al S2 [23] 2010 24 Metformin - PBO (137) DAPA 2·5 mg QD (137) DAPA 5 mg QD (137) DAPA 10 mg QD (135)   
Bolinder J et al [24] 2012 24 N/R Metformin PBO (91) DAPA 10 mg QD (88)     
Rosenstock J et al S2 [25] 2012 24 Pioglitazone Pioglitazone PBO (139) DAPA 5 mg QD (141) DAPA 10 mg QD (140)    
Kaku K et al [5] 2013 12 Naïve - PBO (54) DAPA 1 mg QD (59) DAPA 2.5 mg QD (56) DAPA 5 mg QD (58) DAPA 10 mg QD (52)  
Wilding JPH et al S3 [26] 2012 24 Insulin Insulin PBO (166) DAPA 2.5 mg QD (179) DAPA 5 mg QD (185) DAPA 10 mg QD (173)   
List JF et al [27] 2009 12 Naïve - PBO (54) DAPA 2.5 mg QD (59) DAPA 5 mg QD (58) DAPA 10 mg QD (47) DAPA 20 mg QD (59) DAPA 50 mg QD (56)
  1. n number of patients, N/R not reported, QD once daily, BID twice daily, PBO placebo, CANA canagliflozin, EMPA empagliflozin, IPRA ipragliflozin, DAPA dapagliflozin.