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Table 4 Gender distribution of HOMA-IR cut-off levels, with their corresponding sensitivity and specificity,for classify of IDF MetS and ATPIII MetS, in diabetic and non-diabetic individuals

From: Insulin resistance (HOMA-IR) cut-off values and the metabolic syndrome in a general adult population: effect of gender and age: EPIRCE cross-sectional study

IDF criteria
Population Criterion of specificity = 0.7 Youden index criterion
  Cut point Sensitivity Specificity Cut point Sensitivity Specificity
 Diabetic       
Men 1.55 0.60 0.70 1.60 0.59 0.74
Women 2.22 0.37 0.70 1.58 0.68 0.46
Non-diabetic       
Men 2.25 0.57 0.70 2.05 0.65 0.64
Women*       
 30 years 2.11 0.77 0.70 2.31 0.71 0.76
 50 years 2.05 0.69 0.70 2.05 0.69 0.70
 70 years 2.38 0.45 0.70 2.53 0.40 0.75
ATP III criteria
Population Criterion of specificity = 0.7 Youden index criterion
  Cut point Sensitivity Specificity Cut point Sensitivity Specificity
 Diabetic       
Men 1.57 0.64 0.70 1.60 0.63 0.73
Women 2.22 0.37 0.70 1.58 0.68 0.46
Non-diabetic       
Men 2.27 0.61 0.70 1.85 0.78 0.57
Women*       
 30 years 2.12 0.79 0.70 2.36 0.73 0.77
 50 years 2.05 0.73 0.70 2.07 0.72 0.71
 70 years 2.37 0.48 0.70 2.47 0.44 0.74
  1. *In non-diabetic females HOMA-IR cut-off values are estimated for 30, 50, and 70 years of age, because there is a non linear effect of age on test performance to classify IDF-defined MetS (P value < 0.001) and ATP III-defined MetS (P value = 0.012).
  2. HOMA-IR, homeostasis model assessment of IR; ATPIII, Third Adult Treatment Panel; IDF, International Diabetes Federation; MetS, Metabolic Syndrome.