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Table 3 Summary of case reports with pituitary and adrenal involvement in patients with lymphoma

From: Pituitary and adrenal involvement in diffuse large B-cell lymphoma, with recovery of their function after chemotherapy

Age/gender

Pathology

Presenting symptoms

Involved sites

Lymphoma treatment

Hormonal treatment

Prognosis, survival

Reference

77/M

NHL diffuse large cell

Hyponatremia, Hypoglycemia, Weakness, Confusion

Pituitary gland, Bilateral adrenal glands

No treatment

T4, GC

Died, 9 weeks

[5]

59/M

DLBCL

Weakness, Ptosis, Mild Hyponatremia, Headache

Pituitary gland, Bilateral adrenal glands

R-CHOP, IT MTX

T4, GC, T, Fludro

Alive, 18 months

[6]

77/M

DLBCL

Fever, Hyponatremia, Ptosis

Pituitary gland, Bilateral adrenal glands, Liver, Spleen, Bone marrow

CHOP, IT MTX

GC

Died, 12 months in remission

[1]

63/M

DLBCL

Polyuria, Polydipsia, Miosis, Ptosis, Hypohidrosis of his left side

Pituitary gland, Bilateral adrenal glands, Lung

R-CHOP, HD-MTX, IT MTX, auto-HSCT

T4, GC, Desmo

Alive, 15 months

This report

  1. M male, NHL non-Hodgkin’s lymphoma, DLBCL diffuse large B-cell lymphoma, CHOP cyclophosphamide, doxorubicin, vincristine, prednisolone, IT intrathecal injection, MTX methotrexate, R-CHOP rituximab combined with CHOP.
  2. HD high dose, auto-HSCT autologous hematopoietic stem cell transplantation, T4 thyroxin, GC glucocorticoid, T testosterone, Desmo desmopressin, Fludro fludrocortisone.