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Table 5 Linear regression: between serum 25-hydroxyvitamin D levels and genotype scores for rs2282679 , rs2298849, rs12785878

From: Polymorphisms in GC and NADSYN1 Genes are associated with vitamin D status and metabolic profile in Non-diabetic adults

  

Simple linear regression

Multiple linear regression**

 

Genotype score

Beta*

P

R2for the model

Beta*

P

R2for the model

Model 1a risk allele G for rs2282679 T > G

2 (vs 1)

−2.5

0.04

0.01

−2.6

0.03

0.06

Model 1b risk allele T for rs2298849 T > C

2 (vs 0–1)

0.70

0.43

0.002

   

Model 1c risk allele G for rs12785878 G > T

2 (vs 0–1)

−1.5

0.04

0.01

−2.1

0.02

0.06

Model 2

       

risk alleles G

       

for rs2282679 T > G and rs12785878 G > T

2 (vs 0–1)

−1.8

0.04

0.03

−1.6

0.06

0.08

 

3 (vs 0–1)

−5.4

0.02

 

−5.5

0.001

 
  1. Model 1a, 1b include genotype scores for each SNP alone. Model 2 includes genotype scores for rs2282679 and rs12785878 combined.
  2. Genotype score equals the sum of the number of risk alleles.*Beta: average change in serum 25(OH)D level (ng/mL) associated with the genotype. Regression: ** with adjustment for age, sex, BMI.