Table 2 Distribution of 25(OH)D levels and metabolic parameters according to genotypes of GC and NADSYN1 genes
Genotypes | Dominant model | Recessive model | ||||
|---|---|---|---|---|---|---|
rs2282679 T > G (GC) | GG | TG | TT | P* | ||
(N = 323) | 0 | 43 | 280 | |||
25 (OH)D (ng/mL) | __ | 26.4 ± 8.3 | 29.0 ± 7.4 | 0.03 | __ | __ |
Vitamin D Insufficiency | __ | 72% | 54% | 0.03 | __ | __ |
Vitamin D Deficiency | __ | 19% | 6% | 0.01 | __ | __ |
Overweight | __ | 67% | 60% | 0.37 | __ | __ |
Obesity | __ | 35% | 28% | 0.37 | __ | __ |
Abdominal obesity | __ | 42% | 34% | 0.36 | __ | __ |
Dyslipidemia | __ | 44% | 60% | 0.05 | __ | __ |
rs2298849 T > C (GC) | CC | TC | TT | P* | P | P |
(N = 323) | 49 | 165 | 109 | |||
25 (OH)D (ng/mL) | 28.3 ± 6.9 | 28.5 ± 7.7 | 29.0 ± 7.8 | 0.87 | 0.60 | 0.76 |
Vitamin D Insufficiency | 53% | 60% | 53% | 0.46 | 0.37 | 0.58 |
Vitamin D Deficiency | 6% | 5% | 14% | 0.03 | 0.007 | 0.50 |
Overweight | 51% | 61% | 66% | 0.20 | 0.21 | 0.11 |
Obesity | 22% | 32% | 28% | 0.46 | 0.85 | 0.26 |
Abdominal obesity | 28% | 39% | 33% | 0.32 | 0.37 | 0.27 |
Dyslipidemia | 53% | 63% | 51% | 0.13 | 0.11 | 0.48 |
rs12785878 G > T | TT | GT | GG | P* | P | P |
( NADSYN1 )(N = 318) | 15 | 106 | 197 | |||
25 (OH)D (ng/mL) | 27.7 ± 7.1 | 30.2 ± 8.3 | 27.8 ± 7.1 | 0.05 | 0.03 | 0.69 |
Vitamin D Insufficiency | 53% | 47% | 62% | 0.04 | 0.01 | 0.77 |
Vitamin D Deficiency | 13% | 5% | 10% | 0.25 | 0.23 | 0.46 |
Overweight | 40% | 62% | 62% | 0.22 | 0.60 | 0.08 |
Obesity | 20% | 33% | 28% | 0.50 | 0.85 | 0.40 |
Abdominal obesity | 21% | 39% | 34% | 0.37 | 0.37 | 0.17 |
Dyslipidemia | 60% | 49% | 62% | 0.08 | 0.04 | 0.83 |