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Table 4 Mean ITT changes in A1C (stratified analyses)

From: Real-world utilization patterns and outcomes of colesevelam hcl in the ge electronic medical record

Stratum LOCF within day window Target day Actual day N A1C (%)
Mean Baseline mean Post mean Change mean (95% CI)
Week 16 42 – 140 112      
Monotherapy    97.2 387 7.93 7.52 −0.41 (−0.50, -0.32)
Augment/Switch    97.2 745 8.26 7.90 −0.36 (−0.44, -0.28)
New Combination    96.1 253 8.57 7.69 −0.88 (−1.07, -0.69)
Week 26 42 – 210 182      
Monotherapy    145.0 464 7.95 7.61 −0.34 (−0.43, -0.25)
Augment/Switch    146.9 939 8.29 7.97 −0.31 (−0.39, -0.23)
New Combination    146.0 344 8.55 7.65 −0.90 (−1.08, -0.72)
Week 52 42 – 395 365      
Monotherapy    285.9 367 7.89 7.52 −0.37 (−0.48, -0.26)
Augment/Switch    300.6 939 8.29 7.96 −0.33 (−0.41, -0.25)
New Combination    300.9 441 8.47 7.65 −0.82 (−0.97, -0.67)
  1. P < 0.001 for all based on t-test of change from baseline to last measure within measurement interval; CI: confidence interval.