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Table 4 Comparison between factors and occurrence of adverse reactions, drug choice problems, and dosing problems

From: Drug related problems in type 2 diabetes patients with hypertension: a cross-sectional retrospective study

Factors

Adverse reactions (n = 25) Frequency (Percentage, %)

Drug choice problem (n = 76) Frequency (Percentage, %)

Dosing problem (n = 55) Frequency (Percentage, %)

 

Yes

No

p -value

Yes

No

p -value

Yes

No

p -value

Elderly

Yes

11 (44.0)

74 (42.3)

> 0.999a

28 (36.8)

87 (70.2)

< 0.001a*

34 (61.8)

81 (70.4)

0.548a

No

14 (56.0)

101(57.7)

48 (63.2)

37 (29.8)

21 (38.2)

64 (29.6)

Polypharmacy

Yes

19 (76.0)

134 (76.6)

> 0.999a

60 (78.9)

93 (75.0)

0.640a

38 (69.1)

115 (79.3)

0.182a

No

6 (26.0)

41 (23.4)

16 (21.1)

31 (25.0)

17 (30.9)

30 (20.7)

Duration of hospital stay

≤ 1 week

17 (68.0)

126 (72.0)

0.859a

45 (59.2)

98 (79.0)

0.004a*

40 (72.7)

103 (71.0)

0.951a

> 1 week

8 (32.0)

49 (28.0)

31 (40.8)

26 (21.0)

15 (27.3)

42 (29.0)

Microvascular complications

Yes

17 (68.0)

107 (61.1)

0.660a

53 (69.7)

71 (57.3)

0.106a

40 (72.7)

84 (57.9)

0.078a

No

8 (32.0)

68 (38.9)

23 (30.3)

53 (42.7)

15 (27.3)

61 (42.1)

Cardiovascular events

Yes

12 (48.0)

109 (62.3)

0.193b

47 (61.8)

74 (59.7)

0.877a

36 (65.5)

85 (58.6)

0.471a

No

13 (52.0)

66 (37.7)

29 (38.2)

50 (40.3)

19 (34.5)

60 (41.4)

Renal impairment

Yes

12 (48.0)

88 (50.3)

> 0.999a

46 (60.5)

54 (43.5)

0.029a*

35 (63.6)

65 (44.8)

0.027a*

No

13 (52.0)

87 (49.7)

30 (39.5)

70 (56.5)

20 (36.4)

80 (55.2)

Liver impairment

Yes

1 (4.0)

10 (5.7)

> 0.999b

6 (7.9)

5 (4.0)

0.399a

5 (9.1)

6 (4.1)

0.306a

No

24 (96.0)

165 (94.3)

70 (92.1)

119 (96.0)

50 (90.9)

139 (95.9)

Hyperlipidemia

Yes

7 (28.0)

57 (32.6)

0.819a

17 (22.4)

47 (37.9)

0.033a*

15 (27.3)

49 (33.8)

0.476a

No

18 (72.0)

118 (67.4)

59 (77.6)

77 (62.1)

40 (72.7)

96 (66.2)

  1. a Computed using Continuity Correction; b Computed using Fisher’s Exact Test; * Statistically significant (p < 0.05).