Table 1 Proposed secondary research objectives

Patient, physician and health environment factors associated with:

• Glycemic control

• Hypoglycemia

• Treatment adherence

• Diabetes-related health care utilization

• Diabetes-related health costs

Geographic heterogeneity in:

• Insulin progression rates

• Insulin treatment modality (pen, syringe, pump)

• Glycemic control

• Patterns of T2DM treatment

Challenges associated with insulin use:

• Fasting for religious/cultural reasons

• Health-related quality of life

• Diabetes self-care

• Diabetes knowledge

Patient-provider communication and impact on:

• Insulin progression

• Glycemic control

• Hypoglycemia

• Diabetes self-care

• Diabetes knowledge

• Treatment adherence

Impact of insulin progression on:

• Cardiovascular outcomes

• Hypoglycemia

• Health-related quality of life

• Diabetes distress

• Diabetes self-care

• Health care resource utilization

• Health care costs