The transcription factor 7-like 2 (TCF7L2) polymorphism may be associated with focal arteriolar narrowing in Caucasians with hypertension or without diabetes: the ARIC Study

Table 1 Distribution of selected characteristics by race and rs7903146 genotype status

	African American				Caucasian
	CC	CT	TT	P value^a	CC	CT	TT	P value^a
n	1099	923	177		4105	3321	695
Age, years	58.4 ± 5.6	58.3 ± 5.4	58.9 ± 5.6	0.36	60.1 ± 5.6	59.9 ± 5.6	59.6 ± 5.6	0.03
Male sex	399 (36.31)	353 (38.24)	65 (36.72)	0.66	1894 (46.14)	1528 (46.01)	339 (48.78)	0.39
Current smoker	232 (21.28)	194 (21.20)	34 (19.32)	0.86	672 (16.38)	570 (17.17)	117 (16.83)	0.66
Obesity Present^b	516 (46.95)	418 (45.29)	86 (48.86)	0.60	1223 (29.81)	926 (27.92)	200 (28.78)	0.20
Hypertension Present^c	720 (65.51)	619 (67.06)	116 (65.54)	0.75	1612 (39.28)	1311 (39.48)	262 (37.70)	0.68
Arterial blood pressure, mm Hg^d	94.06 ± 12.87	94.28 ± 12.61	92.98 ± 12.76	0.46	87.83 ± 11.08	87.55 ± 11.38	87.24 ± 11.05	0.32
Diabetes Present^e	283 (25.75)	258 (27.95)	58 (32.77)	0.12	534 (13.01)	536 (16.14)	136 (19.57)	<0.00001
Glucose, mg/dL	119.74 ± 54.11	121.25 ± 57.38	128.02 ± 61.89	0.19	105.80 ± 31.34	108.5 ± 35.47	111.18 ± 36.60	0.00002
Triglycerides, mg/dL	115.99 ± 72.35	113.05 ± 60.12	113.64 ± 59.79	0.60	150.57 ± 91.84	149.22 ± 91.66	151.24 ± 116.54	0.78
HDL-C, mg/dL	55.73 ± 18.84	54.78 ± 17.82	53.90 ± 18.83	0.33	51.08 ± 17.70	51.82 ± 18.54	50.20 ± 17.11	0.05
LDL-C, mg/dL	127.88 ± 36.20	129.15 ± 37.24	130.26 ± 37.15	0.61	126.99 ± 33.10	126.56 ± 34.90	127.03 ± 33.21	0.85
Total Cholesterol, mg/dL	206.43 ± 39.13	206.45 ± 38.71	206.89 ± 39.96	0.99	207.90 ± 36.98	207.94 ± 37.95	206.36 ± 35.65	0.57

Data are means ± SD or n (%) unless otherwise indicated. Abbreviations: HDL-C, high density lipoprotein cholesterol; LDL-C, low density lipoprotein cholesterol. ^a P value is based on ANOVA (continuous) and χ² (categorical), comparing differences for individual characteristic across genotypes; ^bobesity was defined as body mass index ≥30 kg/m²; ^chypertension was defined as systolic blood pressure ≥140 mmHg or diastolic blood pressure ≥90 mmHg or a history of anti-hypertension medication use; ^dmean arterial blood pressure was defined as one-third of systolic blood pressure plus two-thirds of diastolic blood pressure; ^ediabetes was defined as fasting serum glucose levels of at least 7.0 mmol/L (126 mg/dl), nonfasting glucose levels of at least 11.1 mmol/L (200 mg/dl), current use of hypoglycemic medications, or a self-reported physician diagnosis of diabetes.

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