Associations of age with serum insulin, proinsulin and the proinsulin-to-insulin ratio: a cross-sectional study

Bryhni, Bente; Arnesen, Egil; Jenssen, Trond G

doi:10.1186/1472-6823-10-21

BMC Endocrine Disorders

Table 3 Results of multiple regression analysis in women with dependent variables log10(insulin), log10(proinsulin), and log10(proinsulin/insulin).

From: Associations of age with serum insulin, proinsulin and the proinsulin-to-insulin ratio: a cross-sectional study

Independent variable	Log₁₀(insulin) (n = 2928^a) Model R²(adjusted) = 0.37			Log₁₀(proinsulin) (n = 2928^a) Model R²(adjusted) = 0.31			Log₁₀(proinsulin/insulin) (n = 2927^a) Model R²(adjusted) = 0.10
	b	95% CI	p	b	95% CI	p	b	95% CI	p
Age	-0.00404	-0.00496, -0.00312	<0.0001	0.00238	0.00146, 0.00330	<0.0001	0.00642	0.00544, 0.00740	<0.0001
BMI	0.00596	0.00177, 0.01015	0.0053	0.00266	-0.00151, 0.00683	0.2126	-0.00327	-0.00772, 0.00118	0.1494
Waist circumference	0.00333	0.00188, 0.00478	<0.0001	0.00284	0.00139, 0.00429	0.0001	-0.00046	-0.00201, 0.00109	0.5549
Systolic blood pressure	0.00029	-0.00012, 0.00070	0.1678	0.00022	-0.00019, 0.00063	0.3072	-0.00051	-0.00094, -0.00008	0.0229
Heart rate	0.00260	0.00197, 0.00323	<0.0001	0.00125	0.00062, 0.00188	0.0001	-0.00134	-0.00201, -0.00067	0.0001
Serum total cholesterol	-0.01216	-0.01904, -0.00528	0.0005	-0.01510	-0.02196, -0.00824	<0.0001	-0.00293	-0.01024, 0.00438	0.4321
Serum HDL-cholesterol	-0.02992	-0.05097, -0.00887	0.0054	-0.03564	-0.05665, -0.01463	0.0009	-0.00577	-0.02815, 0.01661	0.6131
Serum triglycerides	0.06114	0.04795, 0.07433	<0.0001	0.06283	0.04966, 0.07600	<0.0001	0.00168	-0.01233, 0.01569	0.8140
Serum uric acid	0.00049	0.00035, 0.00063	<0.0001	0.00056	0.00042, 0.00070	<0.0001	0.00007	-0.00009, 0.00023	0.3785
Serum creatinine	0.00047	-0.00016, 0.00110	0.1489	0.00151	0.00088, 0.00214	<0.0001	0.00105	0.00038, 0.00172	0.0023
Log₁₀(γ-glutamyl transferase)	0.08676	0.05236, 0.12116	<0.0001	0.05826	0.02392, 0.09260	0.0009	-0.02875	-0.06530, 0.00780	0.1233
Serum glucose	0.09133	0.08028, 0.10238	<0.0001	0.05747	0.04644, 0.06850	<0.0001	-0.03390	-0.04564, -0.02216	<0.0001
Time from last meal	-0.02572	-0.02989, -0.02155	<0.0001	-0.02091	-0.02508, -0.01674	<0.0001	0.00479	0.00034, 0.00924	0.0346
Coffee consumption	-0.00322	-0.00626, -0.00018	0.0370	-0.00300	-0.00602, 0.00002	0.0522	0.00022	-0.00299, 0.00343	0.8952
Current smoking	-0.04636	-0.06637, -0.02635	<0.0001	-0.01223	-0.03220, 0.00774	0.2302	0.03402	0.01275, 0.05529	0.0017

Non-fasting persons without self-reported diabetes mellitus. The Tromsø Study 1994-95.
^aUsed observations; b, regression coefficient; 95% CI, 95% confidence interval; BMI, body mass index; HDL, high-density lipoprotein

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ISSN: 1472-6823

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