Associations of age with serum insulin, proinsulin and the proinsulin-to-insulin ratio: a cross-sectional study

Bryhni, Bente; Arnesen, Egil; Jenssen, Trond G

doi:10.1186/1472-6823-10-21

BMC Endocrine Disorders

Table 2 Results of multiple regression analysis in men, with dependent variables log10(insulin), log10(proinsulin), and log10(proinsulin/insulin).

From: Associations of age with serum insulin, proinsulin and the proinsulin-to-insulin ratio: a cross-sectional study

Independent variable	Log₁₀(insulin) (n = 2839^a) Model R²(adjusted) = 0.39			Log₁₀(proinsulin) (n = 2840^a) Model R²(adjusted) = 0.33			Log₁₀(proinsulin/insulin) (n = 2839^a) Model R²(adjusted) = 0.08
	b	95% CI	p	b	95% CI	p	b	95% CI	p
Age	-0.00281	-0.00381, -0.00181	<0.0001	0.00292	0.00194, 0.00390	<0.0001	0.00572	0.00470, 0.00674	<0.0001
BMI	0.01170	0.00625, 0.01715	<0.0001	0.00626	0.00089, 0.01163	0.0223	0.00544	-0.00009, 0.01097	0.0542
Waist circumference	0.00383	0.00171, 0.00595	0.0004	0.00440	0.00230, 0.00650	<0.0001	0.00057	-0.00159, 0.00273	0.6028
Systolic blood pressure	-0.00035	-0.00086, 0.00016	0.1719	-0.00034	-0.00085, 0.00017	0.1845	0.00002	-0.00049, 0.00053	0.9533
Heart rate	0.00307	0.00234, 0.00380	<0.0001	0.00165	0.00094, 0.00236	<0.0001	-0.00142	-0.00215, -0.00069	0.0001
Serum total cholesterol	-0.01523	-0.02332, -0.00714	0.0002	-0.01603	-0.02401, -0.00805	<0.0001	-0.00076	-0.00899, 0.00747	0.8565
Serum HDL-cholesterol	-0.07273	-0.09917, -0.04629	<0.0001	-0.06774	-0.09381, -0.04167	<0.0001	0.00499	-0.02192, 0.03190	0.7164
Serum triglycerides	0.05739	0.04426, 0.07052	<0.0001	0.06133	0.04837, 0.07429	<0.0001	0.00389	-0.00948, 0.01726	0.5680
Serum uric acid	0.00043	0.00029, 0.00057	<0.0001	0.00038	0.00024, 0.00052	<0.0001	-0.00005	-0.00019, 0.00009	0.5196
Serum creatinine	0.00033	-0.00010, 0.00076	0.1324	0.00115	0.00072, 0.00158	<0.0001	0.00082	0.00039, 0.00125	0.0003
Log₁₀(γ-glutamyl transferase)	0.09858	0.05903, 0.13813	<0.0001	0.08575	0.04675, 0.12475	<0.0001	-0.01284	-0.05308, 0.02740	0.5317
Serum glucose	0.08659	0.07493, 0.09825	<0.0001	0.05416	0.04267, 0.06565	<0.0001	-0.03244	-0.04430, -0.02058	<0.0001
Time from last meal	-0.02926	-0.03314, -0.02538	<0.0001	-0.02782	-0.03164, -0.02400	<0.0001	0.00144	-0.00250, 0.00538	0.4755
Coffee consumption	-0.00429	-0.00682, -0.00176	0.0009	-0.00172	-0.00421, 0.00077	0.1772	0.00258	0.00001, 0.00515	0.0500
Current smoking	-0.04642	-0.06853, -0.02431	<0.0001	-0.00532	-0.02713, 0.01649	0.6326	0.04105	0.01855, 0.06355	0.0004

Non-fasting persons without self-reported diabetes mellitus. The Tromsø Study 1994-95.
^aUsed observations.; b, regression coefficient; 95% CI, 95% confidence interval; BMI, body mass index; HDL, high-density lipoprotein

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ISSN: 1472-6823

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