Hypothyroidism among military infants born in countries of varied iodine nutrition status

BMC Endocrine Disorders

Table 2 Adjusted odds of congenital hypothyroidism for infants in DoD Birth and Infant Health Registry, born 2000-2004 (N = 447 691)

Variable	No Hypothyroidism (N= 446 993)	Hypothyroidism (N= 698)	OR^a [95% CI]
Birth location
United States	419 091	665	1.00 Reference
Germany	13 669	16	0.82 [0.50, 1.35]
Japan	10 983	11	0.67 [0.37, 1.22]
US territory	3250	6	1.29 [0.57, 2.89]
Sex of infant
Male	229 163	367	1.00 Reference
Female	217 830	331	0.97 [0.84, 1.13]
Infant plurality
Singleton	434 375	646	1.00 Reference
Multiple Birth	12 618	52	0.91 [0.67, 1.23]
Estimated gestational age (weeks)
Full-term (≥37)	407 765	459	1.00 Reference
Preterm (<37)	39 228	239	5.44 [4.60, 6.42]
Maternal age (years)
≤19	27 911	40	1.04 [0.74, 1.45]
20-24	163 852	214	1.00 Reference
25-29	128 777	223	1.32 [1.09, 1.59]
30-34	85 298	135	1.16 [0.93, 1.44]
35-39	34 678	64	1.27 [0.95, 1.69]
≥40	6477	22	2.09 [1.33, 3.30]
Maternal military status
Military	81 633	105	1.00 Reference
Civilian	365 360	593	1.24 [1.00, 1.54]
Military sponsor race/ethnicity
White, non-Hispanic	287 401	433	1.00 Reference
Black, non-Hispanic	76 402	127	1.09 [0.89, 1.33]
Hispanic	42 321	61	1.01 [0.77, 1.33]
Asian/Pacific Islander	16 018	26	1.12 [0.75, 1.66]
American Indian/Alaska Native	5498	12	1.55 [0.87, 2.76]
Other	4600	6	0.88 [0.39, 1.98]
Unknown	14 753	33	1.26 [0.87, 1.81]

DoD, US Department of Defense; OR, adjusted odds ratio; CI, confidence interval.
^aModel adjusted for birth location, sex of infant, infant plurality, estimated gestational age, maternal age, maternal military status, and military sponsor race/ethnicity.

ISSN: 1472-6823